Analytical and Bioanalytical Chemistry

, Volume 407, Issue 19, pp 5661–5671 | Cite as

Raman spectroscopic characterisation of resin-infiltrated hypomineralised enamel

Research Paper


Raman spectroscopy was used to investigate how the effect of pre-treatment protocols, with combinations of hydrochloric acid (HCl), sodium hypochlorite (NaOCl) and hydrogen peroxide (H2O2), for molar–incisor hypo-mineralisation (MIH) altered the penetration depth of polymer infiltrants (ICON, DMG, Hamburg, Germany). Furthermore, the effect on the structure of the MIH portions of the teeth with treatment is examined using multivariate analysis of spectra. It was found that pre-treatment protocols improved penetration depths. The structure of the MIH portion post-treatment appeared much closer to that of normal enamel suggesting a diminution of protein in the MIH region with treatment.


Raman spectroscopy Resin infiltration Hypomineralisation Enamel 

Supplementary material

216_2015_8742_MOESM1_ESM.pdf (530 kb)
ESM 1(PDF 529 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Arun K. Natarajan
    • 1
  • Sara J. Fraser
    • 3
    • 4
  • Michael V. Swain
    • 2
  • Bernadette K. Drummond
    • 1
  • Keith C. Gordon
    • 3
  1. 1.Department of Oral Sciences, Faculty of DentistryUniversity of OtagoDunedinNew Zealand
  2. 2.Biomaterials Science Research Unit, Faculty of DentistryUniversity of Sydney, Sydney Dental HospitalSurry HillsAustralia
  3. 3.MacDiarmid Institute of Advanced Materials and Nanotechnology, Department of ChemistryUniversity of OtagoDunedinNew Zealand
  4. 4.Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of HelsinkiHelsinkiFinland

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