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Analytical and Bioanalytical Chemistry

, Volume 406, Issue 22, pp 5359–5367 | Cite as

Thermoresponsive ketoprofen-imprinted monolith prepared in ionic liquid

  • Xuan Sun
  • Chun-Yan Zhao
  • Xian-Hua Wang
  • Yan-Ping Huang
  • Zhao-Sheng LiuEmail author
Research Paper

Abstract

A thermoresponsive imprinted monolith with the ability of molecular recognition for ketoprofen was prepared for the first time. The smart monolith was synthesized in a stainless steel column using acrylamide (AAm) and 2-acrylamide-2-methyl propanesulfonic acid (AMPS) as functional monomers, which can form interpolymer complexation to restrict access of the analyte to the imprinted networks at low temperatures. To avoid a high back pressure of the column derived from neat dimethyl sulfoxide (DMSO) as a porogenic solvent that is needed to solve polar AMPS, an ionic liquid, [BMIM]BF4, was introduced into the pre-polymerization mixture. The molecular recognition ability towards ketoprofen of the resulting thermoresponsive molecularly imprinted polymer (MIP) monolith displayed significant dependence on temperature compared with a non-imprinted column (NIP), and the greatest imprinting factor was achieved at the transition temperature of 35 °C (above 10). Furthermore, the number of binding sites of the smart MIP monolith at 35 °C was about 76 times as large as that at 25 °C. In addition, Freundlich analyses indicated that the thermoresponsive MIP monolith had homogeneous affinity sites at both 25 and 35 °C with heterogeneity index 0.9251 and 0.9851, respectively.

Keywords

Molecularly imprinted polymer Ketoprofen Monolith Thermoresponsive Molecular recognition 

Notes

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 21375096).

Supplementary material

216_2014_7932_MOESM1_ESM.pdf (688 kb)
ESM 1 (PDF 687 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Xuan Sun
    • 1
  • Chun-Yan Zhao
    • 1
  • Xian-Hua Wang
    • 1
  • Yan-Ping Huang
    • 1
  • Zhao-Sheng Liu
    • 1
    Email author
  1. 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of PharmacyTianjin Medical UniversityTianjinChina

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