Analytical and Bioanalytical Chemistry

, Volume 406, Issue 3, pp 831–839 | Cite as

Preparation of magnetic dummy molecularly imprinted polymers for selective extraction and analysis of salicylic acid in Actinidia chinensis

  • Qing-Ping You
  • Mi-Jun Peng
  • Yu-Ping Zhang
  • Jun-Fang Guo
  • Shu-Yun ShiEmail author
Research Paper


Compounds with strong intramolecular hydrogen bonds (e.g., salicylic acid) have weak intermolecular hydrogen bonding interactions between them and functional monomers in the imprinting process. Consequently, the corresponding molecularly imprinted polymers (MIPs) have no specific adsorption ability. Here, the first magnetic dummy MIPs (MDMIPs) based on benzonic acid as dummy template are successfully developed and evaluated with respect to the applications in selective enrichment and analysis of salicylic acid from complex mixtures. Various parameters affecting absorption/desorption were evaluated for achieving optimal recovery and reducing nonspecific interactions. The prepared MDMIPs showed high adsorption capacity, good selectivity, rapid kinetic binding (40 min) and magnetic separation (5 s), high reproducibility (RSD< 4 % for batch-to-batch evaluation), and stability (only 4 % decrease after 6 cycles). Owing to the efficacy in specific binding and removal of interference, trace level salicylic acid was quantified (0.2 μg/g of fresh mass) in Actinidia chinensis by high-performance liquid chromatography.


Molecularly imprinted polymers Magnetic separation Salicylic acid Actinidia chinensis 



This project was supported by the National Natural Science Foundation of China (21275163, 21005089), the Science and Technology Program of Hunan Province, China (2012FJ2006), the Postdoctoral Science Foundation of Central South University, the Shenghua Yuying project of Central South University, and aid program for Science and Technology Innovative Research Team (Chemicals of Forestry Resources and Development of Forest Products) in Higher Educational Institutions of Hunan Province.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Qing-Ping You
    • 1
  • Mi-Jun Peng
    • 1
    • 2
  • Yu-Ping Zhang
    • 1
  • Jun-Fang Guo
    • 1
  • Shu-Yun Shi
    • 1
    • 3
    Email author
  1. 1.School of Chemistry and Chemical EngineeringCentral South UniversityChangshaChina
  2. 2.Key Laboratory of Hunan Forest Products and Chemical Industry EngineeringJishou UniversityZhangjiajieChina
  3. 3.Key Laboratory of Resources Chemistry of Nonferrous MetalsCentral South UniversityChangshaChina

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