Analytical and Bioanalytical Chemistry

, Volume 406, Issue 4, pp 1011–1027 | Cite as

Reconstitution of supramolecular organization involved in energy metabolism at electrochemical interfaces for biosensing and bioenergy production

  • M. Roger
  • A. de Poulpiquet
  • A. Ciaccafava
  • M. Ilbert
  • M. Guiral
  • M. T. Giudici-Orticoni
  • E. Lojou
Review

Abstract

How the redox proteins and enzymes involved in bioenergetic pathways are organized is a relevant fundamental question, but our understanding of this is still incomplete. This review provides a critical examination of the electrochemical tools developed in recent years to obtain knowledge of the intramolecular and intermolecular electron transfer processes involved in metabolic pathways. Furthermore, better understanding of the electron transfer processes associated with energy metabolism will provide the basis for the rational design of biotechnological devices such as electrochemical biosensors, enzymatic and microbial fuel cells, and hydrogen production factories. Starting from the redox complexes involved in two relevant bacterial chains, i.e., from the hyperthermophile Aquifex aeolicus and the acidophile Acidithiobacillus ferrooxidans, examination of protein–protein interactions using electrochemistry is first reviewed, with a focus on the orientation of a protein on an electrochemical interface mimic of a physiological interaction between two partners. Special attention is paid to current research in the electrochemistry of essential membrane proteins, which is one mandatory step toward the understanding of energy metabolic pathways. The complex and challenging architectures built to reconstitute a membrane-like environment at an electrode are especially considered. The role played by electrochemistry in the attempt to consider full bacterial metabolism is finally emphasized through the study of whole cells immobilized at electrodes as suspensions or biofilms. Before the performances of biotechnological devices can be further improved to make them really attractive, questions remain to be addressed in this particular field of research. We discuss the bottlenecks that need to be overcome in the future.

Keywords

Protein orientation Membrane protein Metabolism Bioenergetics Electrochemistry 

Abbreviations

CcO

Cytochrome c oxidase

DET

Direct electron transfer

DvH

Desulfovibrio vulgaris Hildenborough

PMIRRAS

Polarization-modulation infrared reflection–adsorption spectroscopy

QCM

Quartz crystal microbalance

SAM

Self-assembled monolayer

SEIRA

Surface-enhanced infrared absorption

SHE

Standard hydrogen electrode

t-BLM

Tethered bilayer lipid membrane

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • M. Roger
    • 1
  • A. de Poulpiquet
    • 1
  • A. Ciaccafava
    • 1
  • M. Ilbert
    • 1
  • M. Guiral
    • 1
  • M. T. Giudici-Orticoni
    • 1
  • E. Lojou
    • 1
  1. 1.Unité de Bioénergétique et Ingénierie des Protéines, UMR7281-FR3479, Centre National de la Recherche ScientifiqueAix Marseille UniversitéMarseilleFrance

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