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Analytical and Bioanalytical Chemistry

, Volume 405, Issue 29, pp 9401–9409 | Cite as

Application of a newly developed portable NIR imaging device to monitor the dissolution process of tablets

  • Daitaro Ishikawa
  • Kodai Murayama
  • Kimie Awa
  • Takuma Genkawa
  • Makoto Komiyama
  • Sergei G. Kazarian
  • Yukihiro OzakiEmail author
Research Paper

Abstract

We have recently developed a novel portable NIR imaging device (D-NIRs), which has a high speed and high wavelength resolution. This NIR imaging approach has been developed by utilizing D-NIRs for studying the dissolution of a model tablet containing 20 % ascorbic acid (AsA) as an active pharmaceutical ingredient and 80 % hydroxypropyl methylcellulose, where the tablet is sealed by a special cell. Diffuse reflectance NIR spectra in the 1,000 to 1,600 nm region were measured during the dissolution of the tablet. A unique band at around 1,361 nm of AsA was identified by the second derivative spectra of tablet and used for AsA distribution NIR imaging. Two-dimensional change of AsA concentration of the tablet due to water penetration is clearly shown by using the band-based image at 1,361 nm in NIR spectra obtained with high speed. Moreover, it is significantly enhanced by using the intensity ratio of two bands at 1,361 and 1,354 nm corresponding to AsA and water absorption, respectively, showing the dissolution process. The imaging results suggest that the amount of AsA in the imaged area decreases with increasing water penetration. The proposed NIR imaging approach using the intensity of a specific band or the ratio of two bands combined with the developed portable NIR imaging instrument, is a potentially useful practical way to evaluate the tablet at every moment during dissolution and to monitor the concentration distribution of each drug component in the tablet.

Figure

Visible photo and NIR image for tablet dissolution obtained by using a newly developed portable NIR imaging device: D-NIRs

Keywords

Single wavelength-based image Dissolution process monitoring NIR imaging Pharmaceutical application Portable spectrometer Ratio-based image 

Notes

Acknowledgment

The study was supported by the “Innovation Promotion Program” of the New Energy and Industrial Technology Development Organization (NEDO), Ministry of Economy, Trade and Industry, Japan.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Daitaro Ishikawa
    • 1
  • Kodai Murayama
    • 2
  • Kimie Awa
    • 3
  • Takuma Genkawa
    • 4
  • Makoto Komiyama
    • 2
  • Sergei G. Kazarian
    • 5
  • Yukihiro Ozaki
    • 1
    Email author
  1. 1.School of Science and Technology, Kwansei Gakuin UniversitySandaJapan
  2. 2.Yokogawa Electric CorporationMusashinoJapan
  3. 3.Dainippon Sumitomo Pharma Co., LtdOsakaJapan
  4. 4.Faculty of Life and Environmental SciencesUniversity of TsukubaTsukubaJapan
  5. 5.Department of Chemical EngineeringImperial College LondonLondonUK

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