Analytical and Bioanalytical Chemistry

, Volume 405, Issue 26, pp 8597–8605 | Cite as

Carprofen-imprinted monolith prepared by reversible addition–fragmentation chain transfer polymerization in room temperature ionic liquids

Research Paper

Abstract

To obtain fast separation, ionic liquids were used as porogens first in combination with reversible addition–fragmentation chain transfer (RAFT) polymerization to prepare a new type of molecularly imprinted polymer (MIP) monolith. The imprinted monolithic column was synthesized using a mixture of carprofen (template), 4-vinylpyridine, ethylene glycol dimethacrylate, [BMIM]BF4, and chain transfer agent (CTA). Some polymerization factors, such as template-monomer molar ratio, the degree of crosslinking, the composition of the porogen, and the content of CTA, on the column efficiency and imprinting effect of the resulting MIP monolith were systematically investigated. Affinity screening of structurally similar compounds with the template can be achieved in 200 s on the MIP monolith due to high column efficiency (up to 12,070 plates/m) and good column permeability. Recognition mechanism of the imprinted monolith was also investigated.

Keywords

Carprofen Molecularly imprinted polymers (MIP) Monolith Ionic liquids Reversible addition-fragmentation chain transfer 

Notes

Acknowledgments

This work was supported by the Hundreds Talents Program of the Chinese Academy of Sciences and the National Natural Science Foundation of China (grant no. 21075090).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of PharmacyTianjin Medical UniversityTianjinChina

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