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Analytical and Bioanalytical Chemistry

, Volume 405, Issue 25, pp 7957–7992 | Cite as

Post-column labeling techniques in amino acid analysis by liquid chromatography

  • Pantelis G. RigasEmail author
Review
Part of the following topical collections:
  1. Amino Acid Analysis

Abstract

Amino acid analysis (AAA) has always presented an analytical challenge in terms of sample preparation, separation, and detection. Because of the vast number of amino acids, various separation methods have been applied taking into consideration the large differences in their chemical structures, which span from nonpolar to highly polar side chains. Numerous separation methods have been developed in the past 60 years, and impressive achievements have been made in the fields of separation, derivatization, and detection of amino acids (AAs). Among the separation methods, liquid chromatography (LC) prevailed in the AAA field using either pre-column or post-column labeling techniques in order to improve either separation of AAs or selectivity and sensitivity of AAA. Of the two approaches, the post-column technique is a more rugged and reproducible method and provides excellent AAs separation relatively free from interferences. This review considers current separations combined with post-column labeling techniques for AAA, comparison with the pre-column methods, and the strategies used to develop effective post-column methodology. The focus of the article is on LC methods coupled with post-column labeling techniques and studying the reactions to achieve optimum post-column derivatization (PCD) conditions in order to increase sensitivity and selectivity using various types of detectors (UV–Vis, fluorescence, electrochemical etc.) and illustrating the versatility of the PCD methods for practical analysis.

Figure

Reaction‐detection scheme for the fluorescent derivative of proline with o‐pthalaldehyde reagent

Keywords

Amino acid analysis Derivatization Post-column labeling Liquid chromatography 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Biotoxins and Analytical Chemistry Laboratory, Department of Fisheries and Aquaculture TechnologyAlexander Technological Educational Institute of ThessalonikiN. MoudaniaGreece

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