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Analytical and Bioanalytical Chemistry

, Volume 405, Issue 20, pp 6555–6561 | Cite as

Preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from Curcuma longa L.

  • Tomoko Kitabatake
  • Hiromi Tabo
  • Hisami Matsunaga
  • Jun HaginakaEmail author
Research Paper

Abstract

A monodisperse molecularly imprinted polymer (MIP) for curcumin was first prepared by precipitation polymerization using methacrylamide (MAM) and 4-vinylpyridine as functional co-monomers, divinylbenzene as a crosslinker, and a mixture of acetonitrile and toluene as a porogen. The use of MAM as the co-monomer resulted in the formation of a monodisperse MIP and non-imprinted polymer (NIP). MIP and NIP, respectively, were monodispersed with a narrow particle size distribution (3.3 ± 0.09 and 3.5 ± 0.10 μm). In addition to shape recognition, hydrophobic and hydrogen-bonding interactions affected the retention and molecular-recognition of curcumin on the MIP. The MIP for curcumin could extract curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) in Curcuma longa L.

Figure

MIPs prepared with 4-VPY (left hand) and 4-VPY and MAM (right hand) as the functional monomers were polydispersed and monodispersed, respectively

Keywords

Molecularly imprinted polymer Precipitation polymerization Curcumin Demethoxycurcumin Bisdemethoxycurcumin 

Notes

Acknowledgments

This work was supported in part by the Grant-in-Aid for Scientific Research (B) (No. 19390013) from Japan Society for the Promotion of Science.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Tomoko Kitabatake
    • 1
  • Hiromi Tabo
    • 1
  • Hisami Matsunaga
    • 1
  • Jun Haginaka
    • 1
    Email author
  1. 1.School of Pharmacy and Pharmaceutical SciencesMukogawa Women’s UniversityNishinomiyaJapan

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