Preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from Curcuma longa L.
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A monodisperse molecularly imprinted polymer (MIP) for curcumin was first prepared by precipitation polymerization using methacrylamide (MAM) and 4-vinylpyridine as functional co-monomers, divinylbenzene as a crosslinker, and a mixture of acetonitrile and toluene as a porogen. The use of MAM as the co-monomer resulted in the formation of a monodisperse MIP and non-imprinted polymer (NIP). MIP and NIP, respectively, were monodispersed with a narrow particle size distribution (3.3 ± 0.09 and 3.5 ± 0.10 μm). In addition to shape recognition, hydrophobic and hydrogen-bonding interactions affected the retention and molecular-recognition of curcumin on the MIP. The MIP for curcumin could extract curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin) in Curcuma longa L.
KeywordsMolecularly imprinted polymer Precipitation polymerization Curcumin Demethoxycurcumin Bisdemethoxycurcumin
This work was supported in part by the Grant-in-Aid for Scientific Research (B) (No. 19390013) from Japan Society for the Promotion of Science.
- 8.Abdel-Rehim M, Andersson LI, Altun Z, Blomberg LG (2006) Microextraction in packed syringe online with liquid chromatography-tandem mass spectrometry: molecularly imprinted polymer as packing material for MEPS in selective extraction of ropivacaine from plasma. J Liq Chromatogr Relat Technol 29:1725–1736CrossRefGoogle Scholar
- 21.Jiang M, Zhang J-H, Mei S-R, Shi Y, Zou L-J, Zhu Y-X, Dai K, Lu B (2006) Direct enrichment and high performance liquid chromatography analysis of ultra-trace bisphenol A in water samples with narrowly dispersible bisphenol A imprinted polymeric microspheres column. J Chromatogr A 1110:27–34CrossRefGoogle Scholar
- 24.Valero-Navarro Á, Gómez-Romeroa M, Fernández-Sáncheza JF, Á. Cormack PAG, Segura-Carreteroa A, Fernández-Gutiérreza A (2011) J. Chromatogr. A 1218: 7289–7296Google Scholar
- 29.Azizi ES, Ahmad MN, Islam AKMS, Arbain D, Tahir I (2011) Porogen effect towards the quality of curcumin imprinted polymer. Indones J Chem 11:207–211Google Scholar
- 33.Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (c 1994–2012 ACD/Labs) in SciFinder.Google Scholar