Analytical and Bioanalytical Chemistry

, Volume 405, Issue 19, pp 6165–6180 | Cite as

Plasmonic nanoprobes for intracellular sensing and imaging

  • Hsiangkuo Yuan
  • Janna K. Register
  • Hsin-Neng Wang
  • Andrew M. Fales
  • Yang Liu
  • Tuan Vo-Dinh
Part of the following topical collections:
  1. Optical Nanosensing in Cells


Recent advances in integrating nanotechnology and optical microscopy offer great potential in intracellular applications with improved molecular information and higher resolution. Continuous efforts in designing nanoparticles with strong and tunable plasmon resonance have led to new developments in biosensing and bioimaging, using surface-enhanced Raman scattering and two-photon photoluminescence. We provide an overview of the nanoprobe design updates, such as controlling the nanoparticle shape for optimal plasmon peak position; optical sensing and imaging strategies for intracellular nanoparticle detection; and addressing practical challenges in cellular applications of nanoprobes, including the use of targeting agents and control of nanoparticle aggregation.


Plasmonic nanoprobe characterization (TEM, simulation) and applications in pH sensing, SERS mapping, and TPL imaging


Plasmonic Nanoparticle Surface-enhanced Raman scattering Two-photon photoluminescence Biosensing Cellular imaging 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hsiangkuo Yuan
    • 1
  • Janna K. Register
    • 1
  • Hsin-Neng Wang
    • 1
  • Andrew M. Fales
    • 1
  • Yang Liu
    • 2
  • Tuan Vo-Dinh
    • 1
  1. 1.Fitzpatrick Institute of Photonics, Department of Biomedical EngineeringDuke UniversityDurhamUSA
  2. 2.Fitzpatrick Institute of Photonics, Department of ChemistryDuke UniversityDurhamUSA

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