Advertisement

Analytical and Bioanalytical Chemistry

, Volume 405, Issue 18, pp 5953–5964 | Cite as

Online solid-phase extraction–liquid chromatography–electrospray–tandem mass spectrometry determination of multiple classes of antibiotics in environmental and treated waters

  • Venkata R. Panditi
  • Sudha Rani Batchu
  • Piero R. GardinaliEmail author
Original Paper

Abstract

An online solid-phase extraction and liquid chromatography in combination with tandem mass spectrometry method was developed for the simultaneous determination of 31 antibiotics in drinking water, surface water and reclaimed waters. The developed methodology requires small sample volume (10 mL), very little sample preparation and total sample run time was 20 min. An Ion Max API heated electrospray ionization source operated in the positive mode with two selected reaction monitoring transitions was used per antibiotic for positive identity and quantification performed by the internal standard approach, to correct for matrix effects and any losses in the online extraction step. Method detection limits were in the range of 1.2–9.7, 2.2–15, 5.5–63 ng/L in drinking water, surface water and reclaimed waters, respectively. The method accuracy in matrix spiked samples ranged from 50–150 % for the studied antibiotics. The applicability of the method was demonstrated using various environmental and reclaimed water matrices. Erythromycin was detected in more than 85 % of the samples in all matrices (28–414, n.d.–199, n.d.–66 ng/L in reclaimed, river and drinking waters respectively). The other frequently detected antibiotics in reclaimed waters were nalidixic acid, clarithromycin, azithromycin, trimethoprim, and sulfamethoxazole.

Keywords

Antibiotics Online SPE Reclaimed water Surface water Drinking water Tandem mass spectrometry 

Notes

Acknowledgments

The Environmental Analysis Research Laboratory acknowledges the support from the Thermo Scientific Corporation in the development of this work. Sudha Rani Batchu would like to thank Florida International University graduate school for supporting her through Doctoral Evidence Acquisition Fellowship. This is contribution number 606 from the Southeast Environmental Research Center at Florida International University.

Supplementary material

216_2013_6863_MOESM1_ESM.pdf (666 kb)
ESM 1 (PDF 1406 kb)

References

  1. 1.
    Hernando MD, Mezcua M, Fernandez-Alba AR, Barcelo D (2006) Talanta 69:334–342. doi: 10.1016/j.talanta.2005.09.037 CrossRefGoogle Scholar
  2. 2.
    VanderStichele RH, Elseviers MM, Ferech M, Blot S, Goossens H, Grp EP (2006) J Antimicrob Chemother 58:159–167. doi: 10.1093/jac/dkl147 CrossRefGoogle Scholar
  3. 3.
    Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002) Environ Sci Technol 36:1202–1211. doi: 10.1021/es011055j CrossRefGoogle Scholar
  4. 4.
    Zuccato E, Castiglioni S, Bagnati R, Melis M, Fanelli R (2010) J Hazard Mater 179. doi: 10.1016/j.jhazmat.2010.03.110
  5. 5.
    Chee-Sanford JC, Aminov RI, Krapac IJ, Garrigues-Jeanjean N, Mackie RI (2001) Appl Environ Microbiol 67. doi: 10.1128/aem.67.4.1494-1502.2001
  6. 6.
    Perazzolo C, Morasch B, Kohn T, Magnet A, Thonney D, Chevre N (2010) Environ Toxicol Chem 29. doi: 10.1002/etc.221
  7. 7.
    Wright GD (2010) BMC Biol 8. doi: 10.1186/1741-7007-8-123
  8. 8.
    Verlicchi P, Al Aukidy M, Galletti A, Petrovic M, Barcelo D (2012) Sci Total Environ 430:109–118. doi: 10.1016/j.scitotenv.2012.04.055 CrossRefGoogle Scholar
  9. 9.
    Sim W-J, Lee J-W, Oh J-E (2010) Environ Pollut 158. doi: 10.1016/j.envpol.2009.10.036
  10. 10.
    Yiruhan, Wang Q-J, Mo C-H, Li Y-W, Gao P, Tai Y-P, Zhang Y, Ruan Z-L, Xu J-W (2010) Environ Pollut 158. doi: 10.1016/j.envpol.2010.03.019
  11. 11.
    Li B, Zhang T, Xu Z, Fang HHP (2009) Anal Chim Acta 645. doi: 10.1016/j.aca.2009.04.042
  12. 12.
    Tamtam F, Mercier F, Le Bot B, Eurin J, Dinh QT, Clement M, Chevreuil M (2008) Sci Total Environ 393. doi: 10.1016/j.scitotenv.2007.12.009
  13. 13.
    Ye Z, Weinberg HS, Meyer MT (2007) Anal Chem 79. doi: 10.1021/ac060972a
  14. 14.
    Batt AL, Aga DS (2005) Anal Chem 77. doi: 10.1021/ac048512+
  15. 15.
    Locatelli MAF, Sodre FF, Jardim WF (2011) Arch Environ Contam Toxicol 60. doi: 10.1007/s00244-010-9550-1
  16. 16.
    Garcia-Ac A, Segura PA, Viglino L, Furtos A, Gagnon C, Prevost M, Sauve S (2009) J Chromatogr A 1216. doi: 10.1016/j.chroma.2009.10.015
  17. 17.
    Jesus Garcia-Galan M, Silvia Diaz-Cruz M, Barcelo D (2010) Talanta 81. doi: 10.1016/j.talanta.2009.12.009
  18. 18.
    Pozo OJ, Guerrero C, Sancho JV, Ibanez M, Pitarch E, Hogendoorn E, Hernandez F (2006) J Chromatogr A 1103:83–93. doi: 10.1016/j.chroma.2005.10.073 CrossRefGoogle Scholar
  19. 19.
    Ding J, Ren N, Chen L, Ding L (2009) Anal Chim Acta 634. doi: 10.1016/j.aca.2008.12.022
  20. 20.
    Feitosa-Felizzola J, Temime B, Chiron S (2007) J Chromatogr A 1164. doi: 10.1016/j.chroma.2007.06.071
  21. 21.
    Stoob K, Singer HP, Goetz CW, Ruff M, Mueller SR (2005) J Chromatogr A 1097. doi: 10.1016/j.chroma.2005.08.030
  22. 22.
    Tang HP-O, Ho C, Lai SS-L (2006) Rapid Commun Mass Spectrom 20. doi: 10.1002/rcm.2635
  23. 23.
    Quoc Tuc D, Alliot F, Moreau-Guigon E, Eurin J, Chevreuil M, Labadie P (2011) Talanta 85. doi: 10.1016/j.talanta.2011.05.013
  24. 24.
    Lopez-Serna R, Perez S, Ginebreda A, Petrovic M, Barcelo D (2010) Talanta 83. doi: 10.1016/j.talanta.2010.09.046
  25. 25.
    Gardinali PR, Zhao X (2002) Environ Int 28:521–528CrossRefGoogle Scholar
  26. 26.
    Commission MR (2002) Miami River basin water quality improvement report based on Upper Wagner Creek Pilot ProgramGoogle Scholar
  27. 27.
    Kim YH, Heinze TM, Beger R, Pothuluri JV, Cerniglia CE (2004) Int J Pharm 271:63–76. doi: 10.1016/j.ijpharm.2003.10.023 CrossRefGoogle Scholar
  28. 28.
    Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) Anal Bioanal Chem 391. doi: 10.1007/s00216-008-1854-x
  29. 29.
    Mallet CR, Lu ZL, Mazzeo JR (2004) Rapid Commun Mass Spectrom 18. doi: 10.1002/rcm.1276
  30. 30.
    Yang SW, Cha JM, Carlson K (2005) J Chromatogr A 1097. doi: 10.1016/j.chroma.2005.08.027
  31. 31.
    USEPA (2010) U.S. code of federal regulations, title 40. Part 136, appendix b: definition and procedures for the determination of the method detection limit-revision 1.11. Office of the Federal Register, Washington, DC. USAGoogle Scholar
  32. 32.
    Rao RN, Venkateswarlu N, Narsimha R (2008) J Chromatogr A 1187:151–164. doi: 10.1016/j.chroma.2008.02.021 CrossRefGoogle Scholar
  33. 33.
    Watkinson AJ, Murby EJ, Kolpin DW, Costanzo SD (2009) Sci Total Environ 407:2711–2723. doi: 10.1016/j.scitotenv.2008.11.059 CrossRefGoogle Scholar
  34. 34.
    Segura PA, Garcia-Ac A, Lajeunesse A, Ghosh D, Gagnon C, Sauve S (2007) J Environ Monit 9:307–313. doi: 10.1039/b618801j CrossRefGoogle Scholar
  35. 35.
    Segura PA, Gagnon C, Sauve S (2007) Anal Chim Acta 604:147–157. doi: 10.1016/j.aca.2007.09.058 CrossRefGoogle Scholar
  36. 36.
    Gao LH, Shi YL, Li WH, Niu HY, Liu JM, Cai YQ (2012) Chemosphere 86:665–671. doi: 10.1016/j.chemosphere.2011.11.019 CrossRefGoogle Scholar
  37. 37.
    Nakata H, Kannan K, Jones PD, Giesy JP (2005) Chemosphere 58:759–766. doi: 10.1016/j.chemosphere.2004.08.097 CrossRefGoogle Scholar
  38. 38.
    Gulkowska A, Leung HW, So MK, Taniyasu S, Yamashita N, Yeunq LWY, Richardson BJ, Lei AP, Giesy JP, Lam PKS (2008) Water Res 42:395–403. doi: 10.1016/j.watres.2007.07.031 CrossRefGoogle Scholar
  39. 39.
    (December 2010) Antibiotic sales and use overview 2004–2009Google Scholar
  40. 40.
    Chang XS, Meyer MT, Liu XY, Zhao Q, Chen H, Chen JA, Qiu ZQ, Yang L, Cao J, Shu WQ (2010) Environ Pollut 158:1444–1450. doi: 10.1016/j.envpol.2009.12.034 CrossRefGoogle Scholar
  41. 41.
    Lopes RP, Augusti DV, Oliveira AGM, Oliveira FAS, Vargas EA, Augusti R (2011) Food Addit Contam Part A Chem Anal Control Expo Risk Assess 28:1667–1676. doi: 10.1080/19440049.2011.609136 Google Scholar
  42. 42.
    Masters PA, O’Bryan TA, Zurlo J, Miller DQ, Joshi N (2003) Arch Intern Med 163:402–410. doi: 10.1001/archinte.163.4.402 CrossRefGoogle Scholar
  43. 43.
    Karthikeyan KG, Meyer MT (2006) Sci Total Environ 361:196–207. doi: 10.1016/j.scitotenv.2005.06.030 CrossRefGoogle Scholar
  44. 44.
    Jiang L, Hu XL, Yin DQ, Zhang HC, Yu ZY (2011) Chemosphere 82:822–828. doi: 10.1016/j.chemosphere.2010.11.028 CrossRefGoogle Scholar
  45. 45.
    Bureau USC (2011) State & County QuickFactsGoogle Scholar
  46. 46.
    Lindberg RH, Olofsson U, Rendahl P, Johansson MI, Tysklind M, Andersson BAV (2006) Environ Sci Technol 40:1042–1048. doi: 10.1021/es0516211 CrossRefGoogle Scholar
  47. 47.
    Daughton CG, Ternes TA (1999) Environmental Health Perspectives 107. doi: 10.2307/3434573
  48. 48.
    EPA U (2009) Contaminant Candidate List 3—CCL in drinking watersGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Venkata R. Panditi
    • 1
    • 2
  • Sudha Rani Batchu
    • 1
  • Piero R. Gardinali
    • 1
    • 2
    Email author
  1. 1.Department of Chemistry and BiochemistryFlorida International UniversityNorth MiamiUSA
  2. 2.Southeast Environmental Research CenterFlorida International UniversityMiamiUSA

Personalised recommendations