Water-compatible ‘aspartame’-imprinted polymer grafted on silica surface for selective recognition in aqueous solution
- 750 Downloads
Molecularly imprinted polymers selective for aspartame have been prepared using N-[2-ammonium-ethyl-piperazinium) maleimidopropane sulfonate copolymer bearing zwitterionic centres along the backbone via a surface-confined grafting procedure. Aspartame, a dipeptide, is commonly used as an artificial sweetener. Polymerisation on the surface was propagated by means of Michael addition reaction on amino-grafted silica surface. Electrostatic interactions along with complementary H-bonding and other hydrophobic interactions inducing additional synergetic effect between the template (aspartame) and the imprinted surface led to the formation of imprinted sites. The MIP was able to selectively and specifically take up aspartame from aqueous solution and certain pharmaceutical samples quantitatively. Hence, a facile, specific and selective technique using surface-grafted specific molecular contours developed for specific and selective uptake of aspartame in the presence of various interferrants, in different kinds of matrices is presented.
KeywordsAspartame Dipeptide Molecularly imprinted polymer Sulfobetaine polymer
The work was supported by UGC, new Delhi [F.no.41-331/2012(SR)].
- 12.Yan H, Rowa KH, Yang G (2008) Water-compatible molecularly imprinted polymers for selective extraction of ciprofloxacin from human urine. Talanta 75:227–232Google Scholar
- 13.Zygiel PD, O’Donnell E, Fraier D, Chassaing C, Cormack PAG (2007) Evaluation of water-compatible molecularly imprinted polymers as solid-phase extraction sorbents for the selective extraction of sildenafil and its desmethyl metabolite from plasma samples, J. Chrom B 853:346–353CrossRefGoogle Scholar
- 14.Riskin M, Tel-Vered R, Frasconi M, Willner I (2010) Stereoselective and chiroselective surface plasmon resonance (SPR) analysis of amino acids by molecularly imprinted Au-nanoparticle composites. Chem Eur J 16:7114–7120Google Scholar
- 37.Ranney RE, Oppermann JA (1979) A review of the metabolism of the aspartyl moiety of aspartame in experimental animals and man. J Environ Pathol Toxicol 2:979–985Google Scholar
- 40.Newman LC, Lipton RB (2001) Migraine MLT-Down: an unusual presentation of migraine in patients with aspartame-triggered headaches. Headache 41:899–901Google Scholar
- 58.L. Campanella, Z. Aturki, M.P. Sammartino, J. Pharm. Corporation, Sunnyvale, CA, 1989Google Scholar
- 61.Kumar A, Tarannum N, Singh M (2012) Surface photografting of novel zwitterionic copolymers of maleimide and diamines via Michael-type addition on silica. Mater Sci Appl 3:467–477Google Scholar
- 62.Olsztynska S, Komorowska M, Vrielynck L, Dupuy N (2001) Vibrational spectroscopic study of L-phenylalanine: Effect of pH. Appl Spectrosc 55:901–907Google Scholar
- 65.Willard HH, Merritt LL Jr, Dean JA Jr, Settle FA (1986) Instrumental methods of analysis, 7th edn. Wordsworth Publishing Company, USA, pp 600–603Google Scholar