Analytical and Bioanalytical Chemistry

, Volume 405, Issue 12, pp 4245–4252 | Cite as

Water-compatible ‘aspartame’-imprinted polymer grafted on silica surface for selective recognition in aqueous solution

  • Meenakshi SinghEmail author
  • Abhishek Kumar
  • Nazia Tarannum
Research Paper


Molecularly imprinted polymers selective for aspartame have been prepared using N-[2-ammonium-ethyl-piperazinium) maleimidopropane sulfonate copolymer bearing zwitterionic centres along the backbone via a surface-confined grafting procedure. Aspartame, a dipeptide, is commonly used as an artificial sweetener. Polymerisation on the surface was propagated by means of Michael addition reaction on amino-grafted silica surface. Electrostatic interactions along with complementary H-bonding and other hydrophobic interactions inducing additional synergetic effect between the template (aspartame) and the imprinted surface led to the formation of imprinted sites. The MIP was able to selectively and specifically take up aspartame from aqueous solution and certain pharmaceutical samples quantitatively. Hence, a facile, specific and selective technique using surface-grafted specific molecular contours developed for specific and selective uptake of aspartame in the presence of various interferrants, in different kinds of matrices is presented.


Aspartame Dipeptide Molecularly imprinted polymer Sulfobetaine polymer 



The work was supported by UGC, new Delhi [].


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Meenakshi Singh
    • 1
    Email author
  • Abhishek Kumar
    • 1
  • Nazia Tarannum
    • 1
  1. 1.Department of Chemistry, MMVBanaras Hindu UniversityVaranasiIndia

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