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Analytical and Bioanalytical Chemistry

, Volume 405, Issue 10, pp 3205–3214 | Cite as

Rapid preparation of molecularly imprinted polymer by frontal polymerization

  • Dan-Dan Zhong
  • Xin Liu
  • Qian-Qian Pang
  • Yan-Ping HuangEmail author
  • Zhao-Sheng LiuEmail author
Original Paper

Abstract

Frontal polymerization was successfully applied, for the first time, to obtain molecularly imprinted polymers (MIPs). The method provides a solvent-free polymerization mode, and the reaction can be completed in 30 min. By this approach, MIPs were synthesized using a mixture of levofloxacin (template), methacrylic acid, and divinylbenzene. The effect of template concentration and the amount of comonomer on the imprinting effect of the resulting MIPs was investigated. The textural and morphological parameters of the MIP particles were also characterized by mercury intrusion porosimetry, nitrogen adsorption isotherms, and scanning electron microscopy, providing evidence concerning median pore diameter, pore volumes, and pore size distributions. The levofloxacin-imprinted polymer formed in frontal polymerization mode showed high selectivity, with an imprinting factor of 5.78. The results suggest that frontal polymerization provides an alternative means to prepare MIPs that are difficult to synthesize and may open up new perspectives in the field of MIPs.

Keywords

Frontal polymerization Molecularly imprinted polymer Molecular recognition Affinity Levofloxacin 

Notes

Acknowledgments

This work was supported by the National Natural Science Foundation of China (grant no. 21075090) and the Hundred Talents Program of the Chinese Academy of Sciences.

Supplementary material

216_2013_6722_MOESM1_ESM.pdf (1.9 mb)
ESM 1 (PDF 1903 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of PharmacyTianjin Medical UniversityTianjinChina

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