Analytical and Bioanalytical Chemistry

, Volume 405, Issue 7, pp 2147–2161 | Cite as

Synthesis and theoretical study of molecularly imprinted monoliths for HPLC

  • Chao Zheng
  • Yan-Ping HuangEmail author
  • Zhao-Sheng LiuEmail author


Molecularly imprinted monoliths integrate the high permeability of monolithic materials and the high selectivity and affinity of molecularly imprinted polymers (MIP). Thus, in recent years, development of this novel MIP format in HPLC has expanded quickly, particularly use of organic materials. This review focuses on the principal aspects of good practice in polymerization, theoretical studies, and recent developments in molecularly imprinted monoliths. Some thoughts on perspectives of MIP monoliths are also expressed.


Molecularly imprinted polymer Monolithic column HPLC 



This work was supported by the National Natural Science Foundation of China (grant no. 21075090) and the Hundreds Talents Program of the Chinese Academy of Sciences.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of PharmacyTianjin Medical UniversityTianjinChina

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