Advertisement

Analytical and Bioanalytical Chemistry

, Volume 405, Issue 1, pp 287–295 | Cite as

Potentiometric propranolol-selective sensor based on molecularly imprinted polymer

  • O. GurtovaEmail author
  • L. Ye
  • F. Chmilenko
Original Paper

Abstract

A novel potentiometric sensor based on molecularly imprinted polymer (MIP) for propranolol, an adrenergic-blocking drug, was designed. The influence of molecularly imprinted polymer particle content and sodium tetraphenylborate additives in polyvinylchloride membrane was shown. The electrodes show near-Nernstian responses down to 10−4–10−5 M propranolol concentration. The potentiometric response of MIP-based sensor for propranolol in mixed nonaqueous medium was shown at first. Sensor selectivity relative to various inorganic cations, atenolol and metoprolol, was reported. Direct potentiometry was used to determine propranolol in aqueous modeling solutions and pharmaceutical preparations with good results.

Keywords

Molecular imprinted polymer Propranolol Potentiometric sensor Nanoparticles Anaprilin 

Notes

Acknowledgments

We gratefully acknowledge the financial support from the Swedish Institute via the Visby short-term research stay program and Ukrainian government via the International internship program.

References

  1. 1.
    Holthoff E, Bright F (2007) Anal Chim Acta 594:147–161CrossRefGoogle Scholar
  2. 2.
    Prasada Rao T, Kala R (2008) Talanta 76:485–496CrossRefGoogle Scholar
  3. 3.
    Wulff G (2002) Chem Rev 102:1–28CrossRefGoogle Scholar
  4. 4.
    Ye L, Mosbach K (2008) Chem Mater 20:859–869CrossRefGoogle Scholar
  5. 5.
    Liang R, Zhang R, Qin W (2009) Sensors Actuators B Chem 141:544–550CrossRefGoogle Scholar
  6. 6.
    Prasad K, Prathish KP, Mary Gladis J, Naidu GRK, Prasada Rao T (2007) Sensors Actuators B Chem 123:65–70CrossRefGoogle Scholar
  7. 7.
    Alizadeh T, Akhoundian M (2010) Electrochim Acta 55:3477–3485CrossRefGoogle Scholar
  8. 8.
    Prathish KP, Prasad K, Prasada Rao T, Suryanarayana MVS (2007) Talanta 71:1976–1980CrossRefGoogle Scholar
  9. 9.
    Moreira FTC, Kamel AH, Guerreiro JRL, Sales MGF (2010) Biosens Bioelectron 26:566–574CrossRefGoogle Scholar
  10. 10.
    Rebelo TSCR, Almeida SAA, Guerreiro JRL, Montenegro MCBSM, Sales MGF (2011) Microchem J 98:21–28CrossRefGoogle Scholar
  11. 11.
    Sadeghi S, Fathi F, Abbasifar (2007) J Sensors Actuators B Chem 122:158–164CrossRefGoogle Scholar
  12. 12.
    Guerreiro JRL, Freitas V, Sales MGF (2011) Microchem J 97:173–181CrossRefGoogle Scholar
  13. 13.
    Metilda P, Prasad K, Kala R, Gladis JM, Prasada Rao T, Naidu GRK (2007) Anal Chim Acta 582:147–153CrossRefGoogle Scholar
  14. 14.
    Vishnuvardhan V, Prathish KP, Naidu GRK, Prasada Rao T (2007) Electrochim Acta 52:6922–6928CrossRefGoogle Scholar
  15. 15.
    Prasad K, Kala R, Prasada Rao T, Naidu GRK (2006) Anal Chim Acta 566:69–74CrossRefGoogle Scholar
  16. 16.
    Javanbakht M, Fard SE, Mohammadi A, Abdouss M, Ganjali MR, Norouzi P, Safaraliee L (2008) Anal Chim Acta 612:65–74CrossRefGoogle Scholar
  17. 17.
    D’Agostino G, Alberti G, Biesuz R, Pesavento M (2006) Biosens Bioelectron 22:145–152CrossRefGoogle Scholar
  18. 18.
    Huang J, Xing X, Zhang X, He X, Lin Q, Lian W, Zhu H (2011) Food Res Int 44:276–281CrossRefGoogle Scholar
  19. 19.
    Wang Y, Zhang Z, Jain V, Yi J, Mueller S, Sokolov J, Liu Z, Levon K, Rigas B, Rafailovich MH (2010) Sensors Actuators B Chem 146:381–387CrossRefGoogle Scholar
  20. 20.
    Wang Y, Zhou Y, Sokolov J, Rigas B, Levon K, Rafailovich M (2008) Biosens Bioelectron 24:162–166CrossRefGoogle Scholar
  21. 21.
    Ali SMU, Nur O, Willander M, Danielsson B (2010) Sensors Actuators B Chem 145:869–874CrossRefGoogle Scholar
  22. 22.
    Fulati A, Ali SMU, Asif MH, Alvi NH, Willander M, Brännmark C, Stralfors P, Börjesson SI, Elinder F, Danielsson B (2010) Sensors Actuators B Chem 150:673–680CrossRefGoogle Scholar
  23. 23.
    Zhou Y, Yu B, Levon K (2005) Biosens Bioelectron 20:1851–1855CrossRefGoogle Scholar
  24. 24.
    Chen X, Yang Z, Si S (2009) J Electroanal Chem 635:1–6CrossRefGoogle Scholar
  25. 25.
    Şahin M, Özcan L, Usta B, Şahin Y (2009) Biosens Bioelectron 24:3492–3497CrossRefGoogle Scholar
  26. 26.
    Sabah S, Aghamohammadi M, Alizadeh N (2006) Sensors Actuators B Chem 114:489–496CrossRefGoogle Scholar
  27. 27.
    Zanganeh AR, Amini MK (2007) Electrochim Acta 52:3822–3830CrossRefGoogle Scholar
  28. 28.
    Bendikov TA, Kim J, Harmon TC (2005) Sensors Actuators B Chem 106:512–517CrossRefGoogle Scholar
  29. 29.
    Zanganeh AR, Amini MK (2008) Sensors Actuators B Chem 135:358–365CrossRefGoogle Scholar
  30. 30.
    Riskin M et al (2010) Chem Eur J 16:7114–7120Google Scholar
  31. 31.
    Li C, Wang C, Guan B, Zhang Y, Hu S (2005) Sensors Actuators B Chem 107:411–417CrossRefGoogle Scholar
  32. 32.
    Fernández-Sánchez JF, Carretero AS, Cruces-Blanco C et al (2003) J Pharm Biomed Anal 31:859–865CrossRefGoogle Scholar
  33. 33.
    Pulgarin JAM, Molina AA, Lopez PF (1998) Anal Chim Acta 370:9–18CrossRefGoogle Scholar
  34. 34.
    The 2004 prohibited list, World Anti-Doping Code, Nov. 25 (2003)Google Scholar
  35. 35.
    Aboul-Enein HY, Sun XX (2000) Analusis 28:855–858CrossRefGoogle Scholar
  36. 36.
    Mullett WM, Martín P, Pawliszyn J (2001) Anal Chem 73:2383CrossRefGoogle Scholar
  37. 37.
    Hassan S, Amer M, Abd E-F, El-Kosasy A (1998) Anal Chim Acta 363:81–87CrossRefGoogle Scholar
  38. 38.
    Stefan R, Baiulescu G, Aboul-Enein H (1997) Crit Rev Anal Chem 24:307–321CrossRefGoogle Scholar
  39. 39.
    Chmilenko FA, Korobova IV, Gurtovaya OV, Chmilenko TS (2009) Talanta 78:1259–1265CrossRefGoogle Scholar
  40. 40.
    Chmilenko FA, Korobova IV, Gurtovaya OV (2008) J Anal Chem 63:590–595CrossRefGoogle Scholar
  41. 41.
    Yoshimatsu K, Reimhult K, Krozer A, Mosbach K, Sode K, Ye L (2007) Anal Chim Acta 584:112–121CrossRefGoogle Scholar
  42. 42.
    Singh AK, Saxena P (2005) Talanta 66:993–998CrossRefGoogle Scholar
  43. 43.
    Barbosa J, Burt S, Sanz-Nebot V (1994) Talanta 41:825–831CrossRefGoogle Scholar
  44. 44.
    Janata J (2010) Principles of chemical sensors. Springer, HeidelbergGoogle Scholar
  45. 45.
    Nezamzadeh-Ejhieh A, Badri AJ (2011) Electroanal Chem 660:71–79CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Analytical Chemistry DepartmentOles Honchar Dnipropetrovsk National UniversityDnipropetrovskUkraine
  2. 2.Pure and Applied Biochemistry, Chemical CenterLund UniversityLundSweden

Personalised recommendations