Analytical and Bioanalytical Chemistry

, Volume 403, Issue 8, pp 2071–2076 | Cite as

Calibration of isotope amount ratios by analysis of isotope mixtures

  • Juris Meija


The question as to what constitutes a fully calibrated isotope amount ratio measurement still remains a topic of active research. For years, the definitive calibration approach has been by means of synthetic mixtures of highly enriched isotopes with known chemical purity to give gravimetrically defined ratios. This article outlines the core concepts and assumptions of this method and illustrates the recent developments in the practical metrology of isotope amount ratio measurements.


Metrology Mass spectrometry Isotope amount ratios 


  1. 1.
    DeLaeter J (1998) Mass Spectrom Rev 17:97–125CrossRefGoogle Scholar
  2. 2.
    Nier AO (1939) Phys Rev 55:153–163CrossRefGoogle Scholar
  3. 3.
    Becker P, Bettin H (2011) Philos Trans R Soc A 369:3925–3935CrossRefGoogle Scholar
  4. 4.
    De Laeter J (2011) Mass Spectrom Rev 30:757–771Google Scholar
  5. 5.
    Urey HC (1966) Nobel lectures, chemistry 1922-1941. Elsevier, AmsterdamGoogle Scholar
  6. 6.
    De Laeter JR, Böhlke KJ, De Bièvre P, Hidaka H, Peiser HS, Rosman KJR, Taylor PDP (2003) Pure Appl Chem 75:683–800CrossRefGoogle Scholar
  7. 7.
    Rudge JF, Reynolds BC, Bourdon B (2009) Chem Geol 265:420–431CrossRefGoogle Scholar
  8. 8.
    De Bièvre P, Dybkaer R, Fajgelj A, Hibbert B (2011) Pure Appl Chem 83:1873–1935CrossRefGoogle Scholar
  9. 9.
    Nier AO (1950) Phys Rev 77:789–793CrossRefGoogle Scholar
  10. 10.
    Qi HP, Berglund M, Taylor PDP, Hendrickx F, Verbruggen A, De Bièvre P (1998) Fresenius J Anal Chem 361:767–773CrossRefGoogle Scholar
  11. 11.
    Shields WR, Murphy TJ, Garner EL (1964) J Res Natl Bur Stand 68A:589–592CrossRefGoogle Scholar
  12. 12.
    Catanzaro EJ, Murphy TJ, Garner EL, Shields WR (1964) J Res Natl Bur Stand 68A:593–599CrossRefGoogle Scholar
  13. 13.
    Shields WR, Murphy TJ, Catanzaro EJ, Garner EL (1966) J Res Natl Bur Stand 70A:193–197CrossRefGoogle Scholar
  14. 14.
    Gale NH (1970) Chem Geol 6:305–310CrossRefGoogle Scholar
  15. 15.
    Meija J, Yang L, Caruso JA, Mester Z (2006) J Anal At Spectrom 21:1294–1297CrossRefGoogle Scholar
  16. 16.
    Mana G, Massa E, Valkiers S, Willenberg GD (2010) Int J Mass Spectrom 289:6–10CrossRefGoogle Scholar
  17. 17.
    Powell LJ, Murphy TJ, Gramlich JW (1982) J Res Natl Bur Stand 87:9–19CrossRefGoogle Scholar
  18. 18.
    Henrion A (1994) Fresenius J Anal Chem 350:657–658CrossRefGoogle Scholar
  19. 19.
    Valkiers S, Vendelbo D, Berglund M, De Podesta M (2010) Int J Mass Spectrom 291:41–47CrossRefGoogle Scholar
  20. 20.
    Rienitz O, Pramann A, Schiel D (2010) Int J Mass Spectrom 289:47–53CrossRefGoogle Scholar
  21. 21.
    Mana G, Rienitz O (2010) Int J Mass Spectrom 291:55–60CrossRefGoogle Scholar
  22. 22.
    De Bièvre P, Valkiers S, Peiser HS, Taylor PDP, Hansen P (1996) Metrologia 33:447–455CrossRefGoogle Scholar
  23. 23.
    Yang L, Mester Z, Zhou L, Gao S, Sturgeon RE, Meija J (2011) Anal Chem 83:8999–9004CrossRefGoogle Scholar
  24. 24.
    Marèchal CN, Telouk P, Albarede F (1999) Chem Geol 156:251–273CrossRefGoogle Scholar
  25. 25.
    Meija J, Yang L, Sturgeon RE, Mester Z (2009) Anal Chem 81:6774–6778CrossRefGoogle Scholar
  26. 26.
    Yang L, Meija J (2010) Anal Chem 82:4188–4193CrossRefGoogle Scholar
  27. 27.
    Yang L, Sturgeon RE, Mester Z, Meija J (2010) Anal Chem 82:8978–8982CrossRefGoogle Scholar
  28. 28.
    Valkiers S, Varlam M, Russe K, Berglund M, Taylor P, Wang J, Milton MJT, De Bièvre P (2007) Int J Mass Spectrom 264:10–21CrossRefGoogle Scholar

Copyright information

© Her Majesty the Queen in Right of Canada 2012

Authors and Affiliations

  1. 1.Institute for National Measurement StandardsNational Research Council CanadaOttawaCanada

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