Supramolecular complexes of quantum dots and a polyamidoamine (PAMAM)-folate derivative for molecular imaging of cancer cells
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Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.
KeywordsQuantum dots PAMAM dendrimers Supramolecular complexes Transmission electron microscopy (TEM) Molecular dynamics (MD) simulations Gastric cancer cells
D.A.G. and L.S.S. thank FONDECYT (Postdoctoral Grant 3100037), Proyecto Anillo Científico ACT/24 (F.D.G.N.), and University of Texas at San Antonio (M.J.Y.) for supporting the research activity. This work has been funded in part with funds from the NCI-NIH (Contract No. HHSN261200800001E). The contents of this publication do not necessarily reflect the views or policies of the DHHS, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
- 1.Tomalia DA (2005) Dendrons/dendrimers. The convergence of quantized dendritic building blocks/architectures for applications in nanotechnology. Chim Oggi 23:41–45Google Scholar
- 8.Medintz IL, Mattoussi H, Clapp AR (2008) Potential clinical applications of quantum dots. Int J Nanomed 3:151–167Google Scholar
- 15.Mishra B, Patel BB, Tiwari S (2010) Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomedicine: NBM 6:9–24, and references cited thereinGoogle Scholar
- 18.Turek JJ, Leamon CP, Low PS (1993) Endocytosis of folate-protein conjugates-ultrastructural-localization in Kb cells. J Cell Sci 106:423–430Google Scholar