Analytical and Bioanalytical Chemistry

, Volume 400, Issue 4, pp 931–945 | Cite as

Development and applications of whole cell biosensors for ecotoxicity testing

  • Neil F. Pasco
  • Richard J. Weld
  • Joanne M. Hay
  • Ravi Gooneratne
Review
First Online:
Received:
Revised:
Accepted:

Abstract

Whole cell biosensors are the focus of considerable and increasing interest worldwide as methods for detecting and quantifying environmental toxicity, including biochemical oxygen demand (BOD), heavy metals, antibiotics, pesticides and herbicides. This review follows the development of whole cell biosensors from attempts to utilise changes in cellular metabolism to determine BOD and general toxicity, through the exploitation of unique metabolic pathways to detect specific toxicants, to the increasingly widespread use of genetic engineering to build new, and modify existing, sensing pathways.

Keywords

Microbial biosensors Environmental toxicity Broad response Specific response Engineered response 
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Notes

Acknowledgement

The authors gratefully acknowledge funding from the New Zealand Foundation for Research, Science and Technology.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Neil F. Pasco
    • 1
  • Richard J. Weld
    • 1
  • Joanne M. Hay
    • 1
  • Ravi Gooneratne
    • 2
  1. 1.Lincoln Ventures LtdChristchurchNew Zealand
  2. 2.Lincoln UniversityCanterburyNew Zealand

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