Analytical and Bioanalytical Chemistry

, Volume 399, Issue 5, pp 1735–1741 | Cite as

Critical review or scientific opinion paper: Arsenosugars—a class of benign arsenic species or justification for developing partly speciated arsenic fractionation in foodstuffs?

  • Jörg FeldmannEmail author
  • Eva M. Krupp
Feature Article


In this opinion paper the toxicokinetic behaviour of arsenosugars is reviewed and compared with that of inorganic arsenic and arsenobetaine. It is concluded that the arsenosugars are similar to inorganic arsenic in terms of metabolite formation and tissue accumulation. As a pragmatic means of generating uniform data sets which adequately represent the toxicity of arsenic in food we recommend reporting partly speciated arsenic concentrations in food commodities in three fractions: i) toxic inorganic arsenic as arsenate (after oxidation); ii) arsenobetaine as established non-toxic arsenic; and iii) potentially toxic arsenic, which includes arsenosugars and other organoarsenicals.


arsenic speciation legislation food analysis metabolism accumulation 


  1. 1.
    WHO-IARC, Arsenic in Drinking water. (, 2004
  2. 2.
    European Food Safety Authority (2009) EFSA J 7:1351. p 198Google Scholar
  3. 3.
    Meharg AA, Williams PN, Adamako E, Lawgali YY, Deacon C, Villada A, Cambell CRJ, Sun G, Zhu YG, Feldmann J, Raab A, Zhao FJ, Islam R, Hossain S, Yanai J (2009) Environ Sci Technol 43:1612–1617CrossRefGoogle Scholar
  4. 4.
    Williams PN, Price AH, Raab A, Hossain SA, Feldmann J, Meharg AA (2005) Environ Sci Technol 39:5531–5540CrossRefGoogle Scholar
  5. 5.
    de la Calle MB, Linsinger T, Emteborg H, Charoud-Got J, Verbist I, IMEP-107: Total and inorganic As in rice, JRC/IRMM report EUR24314 EN (2010)Google Scholar
  6. 6.
    Borak J, Hosgood HD (2007) Reg Toxicol Pharmacol 47:204–212CrossRefGoogle Scholar
  7. 7.
    Francesconi KA (2010) Pure Appl Chem 82:373–381CrossRefGoogle Scholar
  8. 8.
    Edmonds JS, Shibata Y, Francesconi KA, Rippingale RJ, Morita M (1997) Appl Organomet Chem 11:281–287CrossRefGoogle Scholar
  9. 9.
    Soeroes C, Goessler W, Francesconi KA, Schmeisser E, Raml R, Kienzl N, Kahn M, Fodor P, Kuehnelt D (2005) J Environ Monit 7:688–692CrossRefGoogle Scholar
  10. 10.
    Kahn M, Raml R, Schmeiser E, Vallant B, Francesconi KA, Goessler W (2005) Environ Chem 2:171–176CrossRefGoogle Scholar
  11. 11.
    Foster S, Maher W, Schmeisser E, Taylor A, Krikowa F, Apte S (2006) Environ Chem 3:304–315CrossRefGoogle Scholar
  12. 12.
    Oya-Ohta Y, Kaise T, Ochi T (1996) Mutat Res 357:123–129Google Scholar
  13. 13.
    Sakurai T (2002) Appl Organomet Chem 16:401–405CrossRefGoogle Scholar
  14. 14.
    Edmonds JS (2003) Francesconi KA in PJ Craig (Ed) Organometallic Chemistry in the Environment. Wiley, Chichester, pp 195–222Google Scholar
  15. 15.
    Kaise T, Watanabe S, Itoh K (1985) Chemosphere 14:1327–1332CrossRefGoogle Scholar
  16. 16.
    Vahter M, Marafante E, Dencker L (1983) Sci Tot Environ 30:197–211CrossRefGoogle Scholar
  17. 17.
    Newcombe C, Raab A, Williams PN, Deacon C, Haris PI, Meharg AA, Feldmann J (2010) J Environ Monit 12:832–837CrossRefGoogle Scholar
  18. 18.
    Raab A, Feldmann J (2005) Anal Bioanal Chem 381:332–338CrossRefGoogle Scholar
  19. 19.
    Yanez J, Fierro V, Mansilla H, Figueroa L, Cornejo L, Barnes RM (2005) J Environ Monit 7:1335–1341CrossRefGoogle Scholar
  20. 20.
    Laberke PJ, Briellmann T, Wittig H, Hausmann R (2009) Rechtsmedizin 19:231–234CrossRefGoogle Scholar
  21. 21.
    Kaise T, Fukui S (1992) Appl Organomet Chem 6:155–169CrossRefGoogle Scholar
  22. 22.
    Gamble BM, Gallagher PA, Shoemaker JA, Wei X, Schwegel CA, Creed JT (2002) Analyst 127:781–785CrossRefGoogle Scholar
  23. 23.
    Francesconi KA, Tanggaard R, McKenzie CJ, Goessler W (2002) Clin Chem 48:92–101Google Scholar
  24. 24.
    van Hulle M, Zhang C, Schotte B, Mees L, Vanhaecke F, Vanholder R, Zhang XR, Cornelis R (2004) J Anal At Spectrom 19:58–64CrossRefGoogle Scholar
  25. 25.
    Le XC, Cullen WR, Reimer KJ (1994) Clin Chem 40:617–624Google Scholar
  26. 26.
    Raml R, Raber G, Rumpler A, Bauernhofer T, Goessler W, Francesconi KA (2009) Chem Res Toxicol 22:1534–1540CrossRefGoogle Scholar
  27. 27.
    Vega L, Styblo M, Patterson R, Cullen W, Wang CQ, Germolec D (2001) Toxicol Appl Pharmacol 172:225–232CrossRefGoogle Scholar
  28. 28.
    Hansen HR, Pickford R, Thomas-Oates J, Jaspars M, Feldmann J (2004) Angew Ch Int Ed 43:337–340CrossRefGoogle Scholar
  29. 29.
    Hansen HR, Raab A, Jaspars M, Milne BF, Feldmann J (2004) Chem Res Toxicol 17:1086–1091CrossRefGoogle Scholar
  30. 30.
    Raml R, Rumpler A, Goessler W, Vahter M, Li L, Ochi T, Francesconi KA (2008) Toxicol Appl Pharmacol 222:374–380CrossRefGoogle Scholar
  31. 31.
    Salim EI, Wanibuchi H, Morimura K, Wei M, Mitsuhashi M, Yoshida K, Endo G, Fukushima S (2003) Carcinogenesis 24:335–342CrossRefGoogle Scholar
  32. 32.
    Ochi T, Kita K, Suzuki T, Rumpler A, Goessler W, Francesconi KA (2008) Toxicol Appl Pharmacol 228:59–67CrossRefGoogle Scholar
  33. 33.
    Andrewes P, Demarini DM, Funasaka K, Wallace K, Lai VWM, Sun HS, Cullen WR, Kitchin KT (2004) Environ Sci Technol 38:4140–4148CrossRefGoogle Scholar
  34. 34.
    Raab A, Wright S, Jaspars M, Meharg A, Feldmann J (2007) Angew Ch Int Ed 46:2594–2597CrossRefGoogle Scholar
  35. 35.
    Hansen HR, Raab A, Francesconi KA, Feldmann J (2003) Environ Sci Technol 37:845–851CrossRefGoogle Scholar
  36. 36.
    Hansen HR, Raab A, Feldmann J (2003) J Anal At Spectrom 18:474–479CrossRefGoogle Scholar
  37. 37.
    Martin SJ, Newcombe C, Raab A, Feldmann J (2005) Environ Chem 2:190–197CrossRefGoogle Scholar
  38. 38.
    Beresford NA, Crout NMJ, Mayes RW (2001) J Agric Sci 136:331–344CrossRefGoogle Scholar
  39. 39.
    Feldmann J, John K, Pengprecha P (2000) Fresenius J Anal Chem 368:116–121CrossRefGoogle Scholar
  40. 40.
    Raab A, Hansen HR, Zhuang L, Feldmann J (2003) Talanta 58:67–76CrossRefGoogle Scholar
  41. 41.
    Caumette G, Ouypornkochagorn S, Scrimgeour CM, Raab A, Feldmann J (2007) Environ Sci Technol 41:2673–2679CrossRefGoogle Scholar
  42. 42.
    Vahter M (2009) Ann Rev Nutr 29:381–399CrossRefGoogle Scholar
  43. 43.
    Niegel C, Matysik FM (2010) Anal Chim Acta 657:83–99CrossRefGoogle Scholar
  44. 44.
    Raab A, Fecher P, Feldmann J (2005) Microchim Acta 151:153–166CrossRefGoogle Scholar
  45. 45.
    Leermakers M, Baeyens W, de Gieter M, Smedts B, Meert C, de Bisschop HC, Morabito R, Quevauviller PH (2006) Trends Anal Chem 25:1–10CrossRefGoogle Scholar
  46. 46.
    Arroyo-Abad U, Mattusch J, Mothes S, Moeder M, Wennrich R, Elizalde-Gonzalez MP, Matysik FM (2010) Talanta 82:38–43CrossRefGoogle Scholar
  47. 47.
    Taleshi MS, Edmonds JS, Goessler W, Ruiz-Chancho MJ, Raber G, Jensen KB, Francesconi KA (2010) Environ Sci Technol 44:1478–1483CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.TESLA Trace Element Speciation LaboratoryUniversity of AberdeenAberdeenUK
  2. 2.ACES Aberdeen Centre for Environmental SustainabilityUniversity of AberdeenAberdeenUK

Personalised recommendations