Analytical and Bioanalytical Chemistry

, Volume 398, Issue 7–8, pp 2949–2954 | Cite as

A one-step etching method to produce gold nanoparticle coated silicon microwells and microchannels

  • Teena James
  • Jeong Hyun Cho
  • Rohan Fernandes
  • Jatinder S. Randhawa
  • David H. Gracias
Technical Note


Gold (Au) nanoparticles (NPs) have large surface areas and novel optical properties and can be readily functionalized using thiol-based chemistry; hence, they are useful in bioanalytical chemistry. Here, we describe a one-step, plasma-etching process that results in the spontaneous formation of Au NP coated recessed microstructures in silicon (Si). Mechanistically, the plasma etch rate of Si was enhanced in the vicinity of 10–100 nm thick Au patterns resulting in the formation of microwells or microchannels uniformly coated with 20–30 nm sized Au NPs. The methodology provides versatility in the types of microstructures that can be formed by varying the shape and dimensions of the Au patterns and the etch time. We also describe selective binding of antibodies to Au NP coated Si microwells using thiol-based surface modification.


Microfluidics Plasma Nanofluidics Nanotechnology 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Teena James
    • 1
  • Jeong Hyun Cho
    • 1
  • Rohan Fernandes
    • 1
  • Jatinder S. Randhawa
    • 1
  • David H. Gracias
    • 1
    • 2
  1. 1.Department of Chemical and Biomolecular EngineeringJohns Hopkins UniversityBaltimoreUSA
  2. 2.Department of ChemistryJohns Hopkins UniversityBaltimoreUSA

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