Analytical and Bioanalytical Chemistry

, Volume 398, Issue 6, pp 2413–2427 | Cite as

Emerging food contaminants: a review

  • Lina Kantiani
  • Marta Llorca
  • Josep Sanchís
  • Marinella Farré
  • Damià Barceló


Governments throughout the world are intensifying their efforts to improve food safety. These efforts come as a response to an increasing number of food-safety problems and increasing consumer concerns. In addition, the variety of toxic residues in food is continuously increasing as a consequence of industrial development, new agricultural practices, environmental pollution, and climate change. This paper reviews a selection of emerging contaminants in food, including the industrial organic pollutants perfluorinated compounds (PFCs), polybrominated diphenyl ethers (PBDEs), and nanomaterials; the pharmaceutical residues antibiotics and coccidiostats; and emerging groups of marine biotoxins. The main analytical approaches for their detection and quantification in food will be presented and discussed with special emphasis on biological techniques, when these are feasible. In the last section, a summary of recent publications reporting the concentrations of these compounds in food will be presented and discussed.


Emerging food contaminants PFCs PBDEs Nanomaterials Antibiotics Biotoxins 



This work was supported by the Spanish Ministry of Science and Innovation, through the project CEMAGUA (CGL2007-64551/HID). Waters is acknowledged for providing the SPE cartridges. Lina Kantiani acknowledges the Generalitat de Catalunya (2009FI_B 00660) and the Alexander S. Onassis foundation (F-ZD 09/2007-2008).


  1. 1.
    Clara M, Scheffknecht C, Scharf S, Weiss S, Gans O (2008) in Water Science and Technology. 58:59–66Google Scholar
  2. 2.
    Carmosini N, Lee LS (2008) Environ Sci Technol 42:6559–6565CrossRefGoogle Scholar
  3. 3.
    Kelly BC, Ikonomou MG, Blair JD, Surridge B, Hoover D, Grace R, Gobas FAPC (2009) Environ Sci Technol 43:4037–4043CrossRefGoogle Scholar
  4. 4.
    Kannan K, Tao L, Sinclair E, Pastva SD, Jude DJ, Giesy JP (2005) Arch Environ Contam Toxicol 48:559–566CrossRefGoogle Scholar
  5. 5.
    Tittlemier SA, Pepper K, Seymour C, Moisey J, Bronson R, Cao XL, Dabeka RW (2007) J Agric Food Chem 55:3203–3210CrossRefGoogle Scholar
  6. 6.
    Powley CR, George SW, Ryan TW, Buck RC (2005) Anal Chem 77:6353–6358CrossRefGoogle Scholar
  7. 7.
    Taniyasu S, Kannan K, Man KS, Gulkowska A, Sinclair E, Okazawa T, Yamashita N (2005) J Chromatogr A 1093:89–97CrossRefGoogle Scholar
  8. 8.
    Martin JW, Kannan K, Berger U, De Voogt P, Field J, Franklin J, Giesy JP, Harner T, Muir DCG, Scott B, Kaiser M, Järnberg U, Jones KC, Mabury SA, Schroeder H, Simcik M, Sottani C, Van Bavel B, Kärrman A, Lindström G, Van Leeuwen S (2004) Environ Sci Technol 38:248A–255ACrossRefGoogle Scholar
  9. 9.
    Wang N, Szostek B, Buck RC, Folsom PW, Sulecki LM, Capka V, Berti WR, Gannon JT (2005) Environ Sci Technol 39:7516–7528CrossRefGoogle Scholar
  10. 10.
    Taniyasu S, Kannan K, Horii Y, Hanari N, Yamashita N (2003) Environ Sci Technol 37:2634–2639CrossRefGoogle Scholar
  11. 11.
    Guruge KS, Manage PM, Yamanaka N, Miyazaki S, Taniyasu S, Yamashita N (2008) Chemosphere 73:S210–S215CrossRefGoogle Scholar
  12. 12.
    Yamashita N, Kannan K, Taniyasu S, Horii Y, Okazawa T, Petrick G, Gamo T (2004) Environ Sci Technol 38:5522–5528CrossRefGoogle Scholar
  13. 13.
    So MK, Taniyasu S, Lam PKS, Zheng GJ, Giesy JP, Yamashita N (2006) Arch Environ Contam Toxicol 50:240–248CrossRefGoogle Scholar
  14. 14.
    Takino M, Daishima S, Nakahara T (2003) Rapid Commun Mass Spectrom 17:383–390CrossRefGoogle Scholar
  15. 15.
    Berger U, Haukas M (2005) J Chromatogr A 1081:210–217CrossRefGoogle Scholar
  16. 16.
    Schwarzer S (2005) E-waste, the hidden side of IT equipment's manufacturing and useGoogle Scholar
  17. 17.
    Vetter W, Von Der Recke R, Symons R, Pyecroft S (2008) Rapid Commun Mass Spectrom 22:4165–4170CrossRefGoogle Scholar
  18. 18.
    von der Recke R, Vetter W (2007) J Chromatogr A 1167:184–194CrossRefGoogle Scholar
  19. 19.
    Shelver WL, Parrotta CD, Slawecki R, Li QX, Ikonomou MG, Barceló D, Lacorte S, Rubio FM (2008) Chemosphere 73:70–75CrossRefGoogle Scholar
  20. 20.
    Xu T, Cho IK, Wang D, Rubio FM, Shelver WL, Gasc AME, Li J, Li QX (2009) Environ Pollut 157:417–422CrossRefGoogle Scholar
  21. 21.
    Ahn KC, Gee SJ, Tsai HJ, Bennett D, Nishioka MG, Blum A, Fishman E, Hammock BD (2009) Environ Sci Technol 43:7784–7790CrossRefGoogle Scholar
  22. 22.
    Marchesini GR, Meimaridou A, Haasnoot W, Meulenberg E, Albertus F, Mizuguchi M, Takeuchi M, Irth H, Murk AJ (2008) Toxicol Appl Pharmacol 232:150–160CrossRefGoogle Scholar
  23. 23.
    Huwe JK, Lorentzsen M, Thuresson K, Bergman A (2002) Chemosphere 46:635–640CrossRefGoogle Scholar
  24. 24.
    Fernandes A, White S, D'Silva K, Rose M (2004) Talanta 63:1147–1155CrossRefGoogle Scholar
  25. 25.
    Martínez A, Ramil M, Montes R, Hernanz D, Rubén E, Rodríguez I, Torrijos RC (2005) J Chromatogr A 1072:83–91CrossRefGoogle Scholar
  26. 26.
    Eljarrat E, De La Cal A, Raldua D, Duran C, Barceló D (2004) Environ Sci Technol 38:2603–2608CrossRefGoogle Scholar
  27. 27.
    Bayen S, Lee HK, Obbard JP (2004) J Chromatogr A 1035:291–294CrossRefGoogle Scholar
  28. 28.
    Gomara B, Herrero L, Bordajandi LR, González MJ (2006) Rapid Commun Mass Spectrom 20:69–74CrossRefGoogle Scholar
  29. 29.
    Larrazábal D (2004) Martínez Mª, Eljarrat E, Barceló D, Fabrellas B. J Mass Spectrom 39:1168–1175CrossRefGoogle Scholar
  30. 30.
    Wang Y, Yang R, Wang T, Zhang Q, Li Y, Jiang G (2010) Chemosphere 78:772–777CrossRefGoogle Scholar
  31. 31.
    Mizukawa K, Takada H, Takeuchi I, Ikemoto T, Omori K, Tsuchiya K (2009) Mar Pollut Bull 58:1217–1224CrossRefGoogle Scholar
  32. 32.
    Dalläge J, Beens J, Brinkman UAT (2003) J Chromatogr A 1000:69–108CrossRefGoogle Scholar
  33. 33.
    Chaudhry Q, Scotter M, Blackburn J, Ross B, Boxall A, Castle L, Aitken R, Watkins R (2008) Food Addit Contam A Chem Anal Control Expo Risk Assess 25:241–258Google Scholar
  34. 34.
    Sanguansri P, Augustin MA (2006) Trends Food Sci Technol 17:547–556CrossRefGoogle Scholar
  35. 35.
    Kantiani L, Farré M, Sibum M, Postigo C, De Alda ML, Barceló D (2009) Anal Chem 81:4285–4295CrossRefGoogle Scholar
  36. 36.
    Threlfall EJ, Ward LR, Frost JA, Willshaw GA (2000) Int J Food Microbiol 62:1–5CrossRefGoogle Scholar
  37. 37.
    Charm SE, Chi R (1988) J Assoc Off Anal Chem 71:304–316Google Scholar
  38. 38.
    Gaudin V, Maris P, Fuselier R, Ribouchon JL, Cadieu N, Rault A (2004) Food Addit Contam 21:422–433CrossRefGoogle Scholar
  39. 39.
    Loomans EEMG, Van Wiltenburg J, Koets M, Van Amerongen A (2003) J Agric Food Chem 51:587–593CrossRefGoogle Scholar
  40. 40.
    Adrian J, Pinacho DG, Granier B, Diserens JM, Sánchez-Baeza F, Marco MP (2008) Anal Bioanal Chem 391:1703–1712CrossRefGoogle Scholar
  41. 41.
    FitzGerald SP, O'Loan N, McConnell RI, Benchikh ELO, Kane NE (2007) J AOAC Int 90:334–342Google Scholar
  42. 42.
    Pimpitak U, Putong S, Komolpis K, Petsom A, Palaga T (2009) Food Chem 116:785–791CrossRefGoogle Scholar
  43. 43.
    Wu H, Yang W, Ma J (2008) Chemistry Bulletin / Huaxue Tongbao. 71:394–397Google Scholar
  44. 44.
    Thavarungkul P, Dawan S, Kanatharana P, Asawatreratanakul P (2007) Biosens Bioelectron 23:688–694CrossRefGoogle Scholar
  45. 45.
    Gustavsson E, Degelaen J, Bjurling P, Sternesjo A (2004) J Agric Food Chem 52:2791–2796CrossRefGoogle Scholar
  46. 46.
    Sternesjö A, Gustavsson E (2006) J AOAC Int 89:832–837Google Scholar
  47. 47.
    Raz SR, Bremer MGEG, Giesbers M, Norde W (2008) Biosens Bioelectron 24:552–557CrossRefGoogle Scholar
  48. 48.
    Weigel S, Pikkemaat MG, Elferink JWA, Mulder PPJ, Huet AC, Delahaut P, Schittko S, Flerus R, Nielen M (2009) Food Addit Contam A Chem Anal Control Expo Risk Assess 26:441–452Google Scholar
  49. 49.
    Raz SR, Bremer MGEG, Haasnoot W, Norde W (2009) Anal Chem 81:7743–7749CrossRefGoogle Scholar
  50. 50.
    Jiang Z, Li Y, Liang A, Qin A (2008) Luminescence 23:157–162CrossRefGoogle Scholar
  51. 51.
    Adrian J, Pasche S, Diserens JM, Sánchez-Baeza F, Gao H, Marco MP, Voirin G (2009) Biosens Bioelectron 24:3340–3346CrossRefGoogle Scholar
  52. 52.
    Virolainen NE, Pikkemaat MG, Elferink JWA, Karp MT (2008) J Agric Food Chem 56:11065–11070CrossRefGoogle Scholar
  53. 53.
    Moreno-Bondi MC (2009) Anal Bioanal Chem 395:921–946CrossRefGoogle Scholar
  54. 54.
    Bohm DA, Stachel CS, Gowik P (2009) J Chromatogr A 1216:8217–8223CrossRefGoogle Scholar
  55. 55.
    Hsieh SH, Huang HY, Lee S (2009) J Chromatogr A 1216:7186–7194CrossRefGoogle Scholar
  56. 56.
    Peters RJB, Bolck YJC, Rutgers P, Stolker AAM, Nielen MWF (2009) J Chromatogr A 1216:8206–8216CrossRefGoogle Scholar
  57. 57.
    Tang Q, Yang T, Tan X, Luo J (2009) J Agric Food Chem 57:4535–4539CrossRefGoogle Scholar
  58. 58.
    Hammel YA, Mohamed R, Gremaud E, LeBreton MH, Guy PA (2008) J Chromatogr A 1177:58–76CrossRefGoogle Scholar
  59. 59.
    Sheridan RS, Meola JR (1999) J AOAC Int 82:982–990Google Scholar
  60. 60.
    Berrada H, Borrull F, Font G, Marcé RM (2008) J Chromatogr A 1208:83–89CrossRefGoogle Scholar
  61. 61.
    Kukusamude C, Santalad A, Boonchiangma S, Burakham R, Srijaranai S, Chailapakul O (2010) Talanta 81:486–492CrossRefGoogle Scholar
  62. 62.
    Van Holthoon F, Mulder PPJ, van Bennekom EO, Heskamp H, Zuidema T, van Rhijn HA (2010) Anal Bioanal Chem 396:3027–3040CrossRefGoogle Scholar
  63. 63.
    Liu W-L, Lee R-J, Lee M-R (2010) Food Chem 121:797–802CrossRefGoogle Scholar
  64. 64.
    Blasco C, Corcia AD, Picó Y (2009) Food Chem 116:1005–1012CrossRefGoogle Scholar
  65. 65.
    Olejnik M, Szprengier-Juszkiewicz T, Jedziniak P (2009) J Chromatogr A 1216:8141–8148CrossRefGoogle Scholar
  66. 66.
    Paschoal JAR, Reyes FGR, Rath S (2009) Anal Bioanal Chem 394:2213–2221CrossRefGoogle Scholar
  67. 67.
    Zhu Wx, Yang Jz, Wei W, Liu Yf, Zhang Ss (2008) J Chromatogr A 1207:29–37CrossRefGoogle Scholar
  68. 68.
    Lombardo-Agüí M, García-Campaña AM, Gámiz-Gracia L, Cruces Blanco C (2010) J Chromatogr A 1217:2237–2242CrossRefGoogle Scholar
  69. 69.
    Ge S, Yan M, Cheng X, Zhang C, Yu J, Zhao P, Gao W (2010) J Pharm Biomed Anal 52:615–619CrossRefGoogle Scholar
  70. 70.
    Li J, Chen L, Wang X, Jin H, Ding L, Zhang K, Zhang H (2008) Talanta 75:1245–1252CrossRefGoogle Scholar
  71. 71.
    Ciminiello P, Dell'Aversano C, Fattorusso E, Forino M, Magno GS, Tartaglione L, Grillo C, Melchiorre N (2006) Anal Chem 78:6153–6159CrossRefGoogle Scholar
  72. 72.
    Cheun B, Endo H, Hayashi T, Nagashima Y, Watanabe E (1996) Biosens Bioelectron 11:1185–1191CrossRefGoogle Scholar
  73. 73.
    Vieytes MR, Cabado AG, Alfonso A, Louzao MC, Botana AM, Botana LM (1993) Anal Biochem 211:87–93CrossRefGoogle Scholar
  74. 74.
    Hamada-Sato N, Minamitani N, Inaba Y, Nagashima Y, Kobayashi T, Imada C, Watanabe E (2004) Sens mater 16:099–107Google Scholar
  75. 75.
    Alfonso A, Vieytes MR, Yasumoto T, Botana LM (2004) Anal Biochem 326:93–99CrossRefGoogle Scholar
  76. 76.
    Alfonso C, Alfonso A, Vieytes MR, Yasumoto T, Botana LM (2005) Anal Biochem 344:266–274CrossRefGoogle Scholar
  77. 77.
    Gawley RE, Shanmugasundaram M, Thorne JB, Tarkka RM (2005) Toxicon 45:783–787CrossRefGoogle Scholar
  78. 78.
    (1991) Council Directive 91/492/EEC of 15 July 1991, laying down the health conditions for the production and the placing on the market of live bivalve molluscsGoogle Scholar
  79. 79.
    Espiña B, Cagide E, Louzao MC, Fernandez MM, Vieytes MR, Katikou P, Villar A, Jaen D, Maman L, Botana LM (2009) Biosci Rep 29:13–23CrossRefGoogle Scholar
  80. 80.
    Fonfría ES, Vilariño N, Espiña B, Louzao MC, Álvarez M, Molga J, Aríoz R, Botana LM (2010) Anal Chim Acta 657:75–82CrossRefGoogle Scholar
  81. 81.
    Stewart I, Eaglesham GK, Poole S, Graham G, Paulo C, Wickramasinghe W, Sadler R, Shaw GR (2009) Toxicon, article in pressGoogle Scholar
  82. 82.
    Ciminiello P, Dell'Aversano C, Fattorusso E, Forino M, Tartaglione L, Boschetti L, Rubini S, Cangini M, Pigozzi S, Poletti R (2010) Toxicon 55:280–288CrossRefGoogle Scholar
  83. 83.
    González AV, Rodríguez-Velasco ML, Ben-Gigirey B, Botana LM (2006) Toxicon 48:1068–1074CrossRefGoogle Scholar
  84. 84.
    Villar-González A, Rodríguez-Velasco ML, Ben-Gigirey B, Botana LM (2007) Toxicon 49:1129–1134CrossRefGoogle Scholar
  85. 85.
    Amzil Z, Sibat M, Royer F, Masson N, Abadie E (2007) Mar Drugs 5:168–179Google Scholar
  86. 86.
    Gerssen A, Mulder PPJ, McElhinney MA, de Boer J (2009) J Chromatogr A 1216:1421–1430CrossRefGoogle Scholar
  87. 87.
    Guerra P, de la Cal A, Marsh G, Eljarrat E, Barceló D (2009) J Hydrol 369:360–367CrossRefGoogle Scholar
  88. 88.
    Adou K, Bontoyan WR, Sweeney PJ (2001) J Agric Food Chem 49:4153–4160CrossRefGoogle Scholar
  89. 89.
    So MK, Miyake Y, Yeung WY, Ho YM, Taniyasu S, Rostkowski P, Yamashita N, Zhou BS, Shi XJ, Wang JX, Giesy JP, Yu H, Lam PKS (2007) Chemosphere 68:2085–2095CrossRefGoogle Scholar
  90. 90.
    Llorca M, Farré M, Picó Y, Barceló D (2009) J Chromatogr A 1216:7195–7204CrossRefGoogle Scholar
  91. 91.
    Eljarrat E, Barceló D (2004) TrAC, Trends Anal Chem 23:727–736CrossRefGoogle Scholar
  92. 92.
    Peres GT, Rath S, Reyes FGR (2010) Food Control 21:620–625CrossRefGoogle Scholar
  93. 93.
    Cháfer-Pericás C, Maquieira A, Puchades R, Miralles J, Moreno A, Pastor-Navarro N, Espinos F (2010) Anal Chim Acta 662:177–185CrossRefGoogle Scholar
  94. 94.
    Costi EM, Sicilia MD, Rubio S (2010) J Chromatogr A 1217:1447–1454CrossRefGoogle Scholar
  95. 95.
    Maher HM, Youssef RM, Khalil RH, El-Bahr SM (2008) J Chromatogr B Anal Technol Biomed Life Sci 876:175–181CrossRefGoogle Scholar
  96. 96.
    Alfonso C, Alfonso A, Pazos MJ, Vieytes MR, Yasumoto T, Milandri A, Poletti R, Botana LM (2007) Anal Biochem 363:228–238CrossRefGoogle Scholar
  97. 97.
    Gawley RE, Mao H, Haque MM, Thorne JB, Pharr JS (2007) J Org Chem 72:2187–2191CrossRefGoogle Scholar
  98. 98.
    Berger U, Glynn A, Holmstrom KE, Berglund M, Ankarberg EH, Tarnkvist A (2009) Chemosphere 76:799–804CrossRefGoogle Scholar
  99. 99.
    Schuetze A, Heberer T, Effkemann S, Juergensen S (2010) Chemosphere 78:647–652CrossRefGoogle Scholar
  100. 100.
    Gao Z, Xu J, Xian Q, Feng J, Chen X, Yu H (2009) Chemosphere 75:1273–1279CrossRefGoogle Scholar
  101. 101.
    Ciminiello P, Dell'Aversano C, Fattorusso E, Magno S, Tartaglione L, Cangini M, Pompei M, Guerrini F, Boni L, Pistocchi R (2006) Toxicon 47:597–604CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Lina Kantiani
    • 1
  • Marta Llorca
    • 1
  • Josep Sanchís
    • 1
  • Marinella Farré
    • 1
  • Damià Barceló
    • 1
    • 2
  1. 1.Department of Environmental ChemistryIDAEA-CSICBarcelonaSpain
  2. 2.King Saud UniversityRiyadhSaudi Arabia

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