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Analytical and Bioanalytical Chemistry

, Volume 397, Issue 3, pp 991–1007 | Cite as

Immunoassays in microfluidic systems

  • Alphonsus H. C. Ng
  • Uvaraj Uddayasankar
  • Aaron R. WheelerEmail author
Review

Abstract

Immunoassays have greatly benefited from miniaturization in microfluidic systems. This review, which summarizes developments in microfluidics-based immunoassays since 2000, includes four sections, focusing on the configurations of immunoassays that have been implemented in microfluidics, the main fluid handling modalities that have been used for microfluidic immunoassays, multiplexed immunoassays in microfluidic platforms, and the emergence of label-free detection techniques. The field of microfluidic immunoassays is continuously improving and has great promise for the future.

Keywords

Microfluidics/microfabrication Immunoassays/ELISA Biosensors Bioanalytical methods Fluid handling/automation multiplex analysis 

Notes

Acknowledgments

We thank the Natural Sciences and Engineering Research Council of Canada for financial support. ARW thanks the CRC for a Canada Research Chair.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Alphonsus H. C. Ng
    • 1
    • 2
  • Uvaraj Uddayasankar
    • 2
    • 3
  • Aaron R. Wheeler
    • 1
    • 2
    • 3
    Email author
  1. 1.Institute for Biomaterials and Biomedical EngineeringUniversity of TorontoTorontoCanada
  2. 2.The Terrence Donnelly Centre for Cellular and Biomolecular ResearchTorontoCanada
  3. 3.Department of ChemistryUniversity of TorontoTorontoCanada

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