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Analytical and Bioanalytical Chemistry

, Volume 396, Issue 6, pp 1951–1959 | Cite as

Knowledge-technology-based discovery of unauthorized genetically modified organisms

  • Tom Ruttink
  • Dany Morisset
  • Bart Van Droogenbroeck
  • Nada Lavrač
  • Guy L. M. Van Den Eede
  • Jana Žel
  • Marc De Loose
Feature Article

Introduction

Various legislations worldwide provide a framework for the authorization of genetically modified organisms (GMOs) and products derived therefrom [ 1]. Despite these regulations, novel GMOs occasionally enter the market without authorization [ 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22] (Table  1) and are referred to as unauthorized GMOs (UGMs). The presence of UGMs in food and feed raises safety and labeling concerns, and challenges international trade [ 23, 24]. Recently reported UGM incidents have created an urgent need to harmonize regulations at a global level, and call for appropriate strategies to discover UGMs. However, some novel UGMs are intrinsically difficult to detect using current analytical strategies for reasons outlined herein. We therefore propose a paradigm shift in the way UGMs can be discovered: a documentation-based screening for products that potentially contain UGMs using knowledge technologies, followed by analytical...

Keywords

Genetically Modify Authorization Status Coban Genetically Modify Event Documented Information 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

T.R. is supported by the Belgian Federal Public Service for Health, Food Chain Safety and Environment (contract no. RT-06/6 GMOdetec) and a short-term travel grant from the Research Foundation Flanders. D.M. and J.Ž. are supported by the Slovenian Research Agency (contract no. P4-0165 and 2511-06-200510). N.L. is supported by the Slovenian Research Agency (contract no. P2-0103).

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Tom Ruttink
    • 1
  • Dany Morisset
    • 2
  • Bart Van Droogenbroeck
    • 1
  • Nada Lavrač
    • 3
  • Guy L. M. Van Den Eede
    • 4
  • Jana Žel
    • 2
  • Marc De Loose
    • 1
    • 5
  1. 1.Technology & Food Unit—Product Quality and InnovationInstitute for Agricultural & Fisheries Research (ILVO)MerelbekeBelgium
  2. 2.Department of Biotechnology and Systems BiologyNational Institute of BiologyLjubljanaSlovenia
  3. 3.Department of Knowledge TechnologiesJožef Stefan InstituteLjubljanaSlovenia
  4. 4.Institute for Health and Consumer Protection, European CommissionDirectorate General Joint Research CentreIspra (VA)Italy
  5. 5.Department of Molecular GeneticsGhent UniversityGhentBelgium

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