Analytical and Bioanalytical Chemistry

, Volume 396, Issue 1, pp 229–240 | Cite as

Bioconjugated quantum dots as fluorescent probes for bioanalytical applications

  • Manuela F. Frasco
  • Nikos Chaniotakis


Quantum dots (QDs) are inorganic semiconductor nanocrystals that have unique optoelectronic properties responsible for bringing together multidisciplinary research to impel their potential bioanalytical applications. In recent years, the many remarkable optical properties of QDs have been combined with the ability to make them increasingly biocompatible and specific to the target. With this great development, QDs hold particular promise as the next generation of fluorescent probes. This review describes the developments in functionalizing QDs making use of different bioconjugation and capping approaches. The progress offered by QDs is evidenced by examples on QD-based biosensing, biolabeling, and delivery of therapeutic agents. In the near future, QD technology still faces some challenges towards the envisioned broad bioanalytical purposes.


Bioanalytical applications of luminescent quantum dot-bioconjugates


Quantum dots Bioconjugation Fluorescence Biosensing Biolabeling and imaging 



Financial support by Fundação para a Ciência e a Tecnologia (M.F.F., postdoctoral grant SFRH/BPD/40876/2007), and by the European Commission program NANOMYC (contract 036812) is gratefully acknowledged.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Laboratory of Analytical Chemistry, Department of ChemistryUniversity of CreteIraklionGreece

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