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Analytical and Bioanalytical Chemistry

, Volume 394, Issue 3, pp 845–853 | Cite as

Development of an automated chemiluminescence flow-through sensor for the determination of 5-aminosalicylic acid in pharmaceuticals: a comparative study between sequential and multicommutated flow techniques

  • E. J. Llorent-Martínez
  • P. Ortega-Barrales
  • M. L. Fernández de Córdova
  • A. Ruiz-MedinaEmail author
Original Paper

Abstract

This work is aimed at demonstrating the potential of the implementation of automatic flow systems in optosensors using chemiluminescence detection. With this purpose, two automatic methodologies, multicommutation and sequential injection analysis (SIA), have been applied to the analysis of 5-aminosalicylic acid (ASA). The analyte is determined for the first time making use of its chemiluminescence reaction with permanganate anion, previously immobilized on an appropriate solid support in the detection area. First, the study of the most appropriate commercial flow-through cell and the optimum conditions for the reaction were performed. Second, the main differences in terms of flow variables and analytical parameters for multicommutation and SIA approaches were stated. Both methodologies were applied to the determination of the analyte in pharmaceuticals obtaining satisfactory results. Finally, the advantages and disadvantages of both proposed methods and the recoveries obtained from pharmaceuticals were statistically compared.

Keywords

Automation Multicommutation SIA Mesalazine Chemiluminescence 

Notes

Acknowledgments

The authors are grateful to the “Consejería de Innovación, Ciencia y Empresa (Junta de Andalucía)”, Project P07-FQM-02673, for financial support. F. Hermoso-Torres is also acknowledged for the design of the black-box.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • E. J. Llorent-Martínez
    • 1
  • P. Ortega-Barrales
    • 1
  • M. L. Fernández de Córdova
    • 1
  • A. Ruiz-Medina
    • 1
    Email author
  1. 1.Department of Physical and Analytical Chemistry, Faculty of Experimental SciencesUniversity of JaénJaénSpain

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