Analytical and Bioanalytical Chemistry

, Volume 394, Issue 3, pp 679–686 | Cite as

Bioanalytical applications of SERS (surface-enhanced Raman spectroscopy)

  • Stephen D. Hudson
  • George ChumanovEmail author


Surface-enhanced Raman scattering (SERS) is a powerful technique for analyzing biological samples as it can rapidly and nondestructively provide chemical and, in some cases, structural information about molecules in aqueous environments. In the Raman scattering process, both visible and near-infrared (NIR) wavelengths of light can be used to induce polarization of Raman-active molecules, leading to inelastic light scattering that yields specific molecular vibrational information. The development of surface enhancement has enabled Raman scattering to be an effective tool for qualitative as well as quantitative measurements with high sensitivity and specificity. Recent advances have led to many novel applications of SERS for biological analyses, resulting in new insights for biochemistry and molecular biology, the detection of biological warfare agents, and medical diagnostics for cancer, diabetes, and other diseases. This trend article highlights many of these recent investigations and provides a brief outlook in order to assess possible future directions of SERS as a bioanalytical tool.


SERS Optical labels Quantitative SERS Data analysis 



The capped, single Ag NP research from our laboratory was supported by the United States Department of Energy, grant No. DE-FG02-06ER46342.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.235 H.L. Hunter LaboratoriesClemsonUSA

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