Analytical and Bioanalytical Chemistry

, Volume 394, Issue 8, pp 1995–2008

Forensic applications of ambient ionization mass spectrometry

  • Demian R. Ifa
  • Ayanna U. Jackson
  • Giuseppe Paglia
  • R. Graham Cooks
Review

Abstract

This review highlights and critically assesses forensic applications in the developing field of ambient ionization mass spectrometry. Ambient ionization methods permit the ionization of samples outside the mass spectrometer in the ordinary atmosphere, with minimal sample preparation. Several ambient ionization methods have been created since 2004 and they utilize different mechanisms to create ions for mass-spectrometric analysis. Forensic applications of these techniques—to the analysis of toxic industrial compounds, chemical warfare agents, illicit drugs and formulations, explosives, foodstuff, inks, fingerprints, and skin—are reviewed. The minimal sample pretreatment needed is illustrated with examples of analysis from complex matrices (e.g., food) on various substrates (e.g., paper). The low limits of detection achieved by most of the ambient ionization methods for compounds of forensic interest readily offer qualitative confirmation of chemical identity; in some cases quantitative data are also available. The forensic applications of ambient ionization methods are a growing research field and there are still many types of applications which remain to be explored, particularly those involving on-site analysis. Aspects of ambient ionization currently undergoing rapid development include molecular imaging and increased detection specificity through simultaneous chemical reaction and ionization by addition of appropriate chemical reagents.

Keywords

Forensics/toxicology Mass spectrometry plasma mass spectrometry Ambient analysis Illicit drugs Explosives Counterfeit pharmaceuticals 

References

  1. 1.
    Brettell TA, Butler JM, Almirall JR (2007) Anal Chem 79:4365–4384CrossRefGoogle Scholar
  2. 2.
    Brettell TA, Butler JM, Saferstein R (2005) Anal Chem 77:3839–3860CrossRefGoogle Scholar
  3. 3.
    Costello CE, Hertz HS, Sakai T, Biemann K (1974) Clin Chem 20:255–265Google Scholar
  4. 4.
    Kelly RL, Martz RM (1984) J Forensic Sci 29:714–722Google Scholar
  5. 5.
    Choudhary G, Cooper CV (1979) Am Ind Hyg Assoc J 40:39–46Google Scholar
  6. 6.
    Angeletti R, Gioacchini AM, Seraglia R, Piro R, Traldi P (1998) J Mass Spectrom 33:525–531CrossRefGoogle Scholar
  7. 7.
    Di Donna L, Maiuolo L, Mazzotti F, De Luca D, Sindona G (2004) Anal Chem 76:5104–5108CrossRefGoogle Scholar
  8. 8.
    Hart KJ, Wise MB, Griest WH, Lammert SA (2000) Field Anal Chem Technol 4:93–110CrossRefGoogle Scholar
  9. 9.
    Griest WH, Wise MB, Hart KJ, Lammert SA, Thompson CV, Vass AA (2001) Field Anal Chem Technol 5:177–184CrossRefGoogle Scholar
  10. 10.
    Ouyang Z, Cooks RG (2009) Annu Rev Anal Chem 2 (in press)Google Scholar
  11. 11.
    Takats Z, Wiseman JM, Gologan B, Cooks RG (2004) Science 306:471–473CrossRefGoogle Scholar
  12. 12.
    Cody RB, Laramee JA, Durst HD (2005) Anal Chem 77:2297–2302CrossRefGoogle Scholar
  13. 13.
    Cooks RG, Ouyang Z, Takats Z, Wiseman JM (2006) Science 311:1566–1570CrossRefGoogle Scholar
  14. 14.
    Van-Berkel GJ, Pasilis SP, Ovchinnikova O (2008) J Mass Spectrom 43:1161–1180CrossRefGoogle Scholar
  15. 15.
    Harris GA, Nyadong L, Fernandez FM (2008) Analyst 133:1297–1301CrossRefGoogle Scholar
  16. 16.
    Venter A, Nefliu M, Graham Cooks R (2008) Trends Anal Chem 27:284–290CrossRefGoogle Scholar
  17. 17.
    Reid NM, Buckley JA, French JB (1977) UTIAS Tech Note 213:7Google Scholar
  18. 18.
    Cotte-Rodriguez I, Chen H, Cooks RG (2006) Chem Commun 8:953–955CrossRefGoogle Scholar
  19. 19.
    Talaty N, Mulligan CC, Justes DR, Jackson AU, Noll RJ, Cooks RG (2008) Analyst 133:1532–1540CrossRefGoogle Scholar
  20. 20.
    Cotte-Rodriguez I, Cooks RG (2006) Chem Commum 28:2968–2970CrossRefGoogle Scholar
  21. 21.
    Cotte-Rodriguez I, Hernandez-Soto H, Chen H, Cooks RG (2008) Anal Chem 80:1512–1519CrossRefGoogle Scholar
  22. 22.
    Cotte-Rodriguez I, Takats Z, Talaty N, Chen HW, Cooks RG (2005) Anal Chem 77:6755–6764CrossRefGoogle Scholar
  23. 23.
    Justes DR, Talaty N, Cotte-Rodriguez I, Cooks RG (2007) Chem Commun 21:2142–2144CrossRefGoogle Scholar
  24. 24.
    Mulligan CC, Talaty N, Cooks RG (2006) Chem Commun 16:1709–1711CrossRefGoogle Scholar
  25. 25.
    Song Y, Cooks RG (2007) J Mass Spectrom 42:1086–1092CrossRefGoogle Scholar
  26. 26.
    Williams JP, Lock R, Patel VJ, Scrivens JH (2006) Anal Chem 78:7440–7445CrossRefGoogle Scholar
  27. 27.
    Huang G, Chen H, Zhang X, Cooks RG, Ouyang Z (2007) Anal Chem 79:8327–8332CrossRefGoogle Scholar
  28. 28.
    Chen H, Zheng OY, Cooks RG (2006) Angew Chem Int Ed 45:3656–3660CrossRefGoogle Scholar
  29. 29.
    Nyadong L, Green MD, De Jesus VR, Newton PN, Fernandez FM (2007) Anal Chem 79:2150–2157CrossRefGoogle Scholar
  30. 30.
    D'Agostino PA, Chenier CL, Hancock JR, Lepage CRJ (2007) Rapid Commun Mass Spectrom 21:543–549CrossRefGoogle Scholar
  31. 31.
    D'Agostino PA, Hancock JR, Chenier CL (2008) J Chromatogr A 110:86–94Google Scholar
  32. 32.
    Pena-Quevedo AJ, Cody R, Mina N, Ramos M, Hernandez-Rivera SP (2007) Paper presented at the conference on sensors and command, control, communications and intelligence (C3I) technologies for homeland security and homeland defense VI, Orlando, 2007Google Scholar
  33. 33.
    Na N, Zhao MX, Zhang SC, Yang CD, Zhang XR (2007) J Am Soc Mass Spectrom 18:1859–1862CrossRefGoogle Scholar
  34. 34.
    Na N, Zhang C, Zhao MX, Zhang SC, Yang CD, Fang X, Zhang XR (2007) J Mass Spectrom 42:1079–1085CrossRefGoogle Scholar
  35. 35.
    Harper JD, Charipar NA, Mulligan CC, Cooks RG, Ouyang Z (2008) Anal Chem 80:9097–9104CrossRefGoogle Scholar
  36. 36.
    Miao Z, Chen H (2009) J Am Soc Mass Spectrom (in press)Google Scholar
  37. 37.
    Takats Z, Cotte-Rodriguez I, Talaty N, Chen HW, Cooks RG (2005) Chem Commun 1950–1952Google Scholar
  38. 38.
    Chen HW, Zheng J, Zhang X, Luo MB, Wang ZC, Qiao XL (2007) J Mass Spectrom 42:1045–1056CrossRefGoogle Scholar
  39. 39.
    Rodriguez-Cruz SE (2006) Rapid Commun Mass Spectrom 20:53–60CrossRefGoogle Scholar
  40. 40.
    Kauppila TJ, Arvola V, Haapala M, Pol J, Aalberg L, Saarela V, Franssila S, Kotiaho T, Kostiainen R (2008) Rapid Commun Mass Spectrom 22:979–985CrossRefGoogle Scholar
  41. 41.
    Keil A, Talaty N, Janfelt C, Noll RJ, Gao L, Ouyang Z, Cooks RG (2007) Anal Chem 79:7734–7739CrossRefGoogle Scholar
  42. 42.
    Leuthold LA, Mandscheff JF, Fathi M, Giroud C, Augsburger M, Varesio E, Hopfgartner G (2006) Rapid Commun Mass Spectrom 20:103–110CrossRefGoogle Scholar
  43. 43.
    Kauppila TJ, Talaty N, Kuuranne T, Kotiaho T, Kostiainen R, Cooks RG (2007) Analyst 132:868–875CrossRefGoogle Scholar
  44. 44.
    Lin ZQ, Zhang SC, Zhao MX, Yang CD, Chen DP, Zhang XR (2008) Rapid Commun Mass Spectrom 22:1882–1888CrossRefGoogle Scholar
  45. 45.
    Fernandez FM, Green MD, Newton PN (2008) Ind Eng Chem Res 47:585–590CrossRefGoogle Scholar
  46. 46.
    Fernandez FM, Cody RB, Green MD, Hampton CY, McGready R, Sengaloundeth S, White NJ, Newton PN (2006) ChemMedChem 1:702CrossRefGoogle Scholar
  47. 47.
    Ricci C, Nyadong L, Fernandez FM, Newton PN, Kazarian SG (2007) Anal Bioanal Chem 387:551–559CrossRefGoogle Scholar
  48. 48.
    Nyadong L, Late S, Green MD, Banga A, Fernandez FM (2008) J Am Soc Mass Spectrom 19:380–388CrossRefGoogle Scholar
  49. 49.
    Ifa DR, Manicke NE, Rusine AL, Cooks RG (2008) Rapid Commun Mass Spectrom 22:503–510CrossRefGoogle Scholar
  50. 50.
    Nyadong L, Hohenstein EG, Johnson K, Sherrill CD, Green MD, Fernández FM (2008) Analyst 133:1513–1522CrossRefGoogle Scholar
  51. 51.
    Chingin K, Gamez G, Chen HW, Zhu L, Zenobi R (2008) Rapid Commun Mass Spectrom 22:2009–2014CrossRefGoogle Scholar
  52. 52.
    Haddad R, Catharino RR, Marques LA, Eberlin MN (2008) Rapid Commun Mass Spectrom 22:3662–3666CrossRefGoogle Scholar
  53. 53.
    FDA (200) Pet food recall/tainted animal feed. http://www.fda.gov/oc/opacom/hottopics/petfood.html
  54. 54.
    Vail TM, Jones PR, Sparkman OD (2007) J Anal Toxicol 31:304–312Google Scholar
  55. 55.
    Huang G, Ouyang Z, Cooks RG (2009) Chem Commun 556–558.Google Scholar
  56. 56.
    Zhu L, Gamez G, Chen H, Chingin K, Zenobi R (2009) Chem Commun 559–561.Google Scholar
  57. 57.
    Cajka T, Vaclavik L, Riddellova K, Hajslova J (2008) LC GC Eur 21:250–256Google Scholar
  58. 58.
    Jecklin MC, Gamez G, Touboul D, Zenobi R (2008) Rapid Commun Mass Spectrom 22:2791–2798CrossRefGoogle Scholar
  59. 59.
    García-Reyes JF, Jackson AU, Molina-Díaz A, Cooks RG (2009) Anal Chem 81:820–829CrossRefGoogle Scholar
  60. 60.
    Jones RW, Cody RB, McClelland JF (2006) J Forensic Sci 51:915–918CrossRefGoogle Scholar
  61. 61.
    Ifa DR, Gumaelius LM, Eberlin LS, Manicke NE, Cooks RG (2007) Analyst 132:461–467CrossRefGoogle Scholar
  62. 62.
    Ifa DR, Wiseman JM, Song QY, Cooks RG (2007) Int J Mass Spectrom 259:8–15CrossRefGoogle Scholar
  63. 63.
    Kertesz V, Van Berkel GJ (2008) Rapid Commun Mass Spectrom 22:2639–2644CrossRefGoogle Scholar
  64. 64.
    Huang MZ, Hsu HJ, Wu CI, Lin SY, Ma YL, Cheng TL, Shiea J (2007) Rapid Commun Mass Spectrom 21:1767–1775CrossRefGoogle Scholar
  65. 65.
    Ifa DR, Manicke NE, Dill AL, Cooks RG (2008) Science 321:805–805CrossRefGoogle Scholar
  66. 66.
    Laranee JA, Cody RB, Nilles JM, Durst HD (2007) In: Blackledge RD (ed) Forensic analysis on the cutting edge: new methods for trace evidence analysis. Wiley, Hoboken, pp 180–181Google Scholar
  67. 67.
    Chen H, Yang S, Wortmann A, Zenobi R (2007) Angew Chem Int Ed 46:7591–7594CrossRefGoogle Scholar
  68. 68.
    Chen HW, Wortmann A, Zenobi R (2007) J Mass Spectrom 42:1123–1135CrossRefGoogle Scholar
  69. 69.
    Zhao MX, Zhang SC, Yang CD, Xu YC, Wen YX, Sun LS, Zhang XR (2008) J Forensic Sci 53:807–811CrossRefGoogle Scholar
  70. 70.
    Venter A, Cooks RG (2008) Anal Chem 79:6398–6403CrossRefGoogle Scholar
  71. 71.
    Gao L, Cooks RG, Ouyang Z (2008) Anal Chem 80:4026–4032CrossRefGoogle Scholar
  72. 72.
    McEwen CN, McKay RG, Larsen BS (2005) Anal Chem 77:7826–7831CrossRefGoogle Scholar
  73. 73.
    Haapala M, Pol J, Saarela V, Arvola V, Kotiaho T, Ketola RA, Franssila S, Kauppila TJ, Kostiainen R (2007) Anal Chem 79:7867–7872CrossRefGoogle Scholar
  74. 74.
    Haddad R, Sparrapan R, Kotiaho T, Eberlin MN (2008) Anal Chem 80:898–903CrossRefGoogle Scholar
  75. 75.
    Shiea J, Huang MZ, Hsu HJ, Lee CY, Yuan CH, Beech I, Sunner J (2005) Rapid Commun Mass Spectrom 19:3701–3704CrossRefGoogle Scholar
  76. 76.
    Chen HW, Venter A, Cooks RG (2006) Chem Commun 2042–2044Google Scholar
  77. 77.
    Shieh IF, Lee CY, Shiea J (2005) J Proteome Res 4:606–612CrossRefGoogle Scholar
  78. 78.
    Andrade FJ, Shelley JT, Wetzel WC, Webb MR, Gamez G, Ray SJ, Hieftje GM (2008) Anal Chem 80:2654–2663CrossRefGoogle Scholar
  79. 79.
    Nemes P, Vertes A (2007) Anal Chem 79:8098–8106CrossRefGoogle Scholar
  80. 80.
    Sampson JS, Hawkridge AM, Muddiman DC (2006) J Am Soc Mass Spectrom 17:1712–1716CrossRefGoogle Scholar
  81. 81.
    Ratcliffe LV, Rutten FJM, Barrett DA, Whitmore T, Seymour D, Greenwood C, Aranda-Gonzalvo Y, Robinson S, McCoustrat M (2007) Anal Chem 79:6094–6101CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Demian R. Ifa
    • 1
  • Ayanna U. Jackson
    • 1
  • Giuseppe Paglia
    • 1
    • 2
  • R. Graham Cooks
    • 1
  1. 1.Department of ChemistryPurdue UniversityWest LafayetteUSA
  2. 2.Department of Biomedical Sciences, Faculty of MedicineUniversity of FoggiaFoggiaItaly

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