Advertisement

Analytical and Bioanalytical Chemistry

, Volume 390, Issue 2, pp 617–628 | Cite as

Stable isotope dilution assays in mycotoxin analysis

  • Michael RychlikEmail author
  • Stefan Asam
Review

Abstract

The principle and applications of stable isotope dilution assays (SIDAs) in mycotoxin analysis are critically reviewed. The general section includes historical aspects of SIDAs, the prerequisites and limitations of the use of stable isotopically labelled internal standards, and possible calibration procedures. In the application section actual SIDAs for the analysis of trichothecenes, zearalenone, fumonisins, patulin, and ochratoxin A are presented. The syntheses and availability of labelled mycotoxins for use as internal standards is reviewed and specific advances in food analysis and toxicology are demonstrated. The review indicates that LC–MS applications, in particular, require the use of stable isotopically labelled standards to compensate for losses during clean-up and for discrimination due to ion suppression. As the commercial availability of these compounds continues to increase, SIDAs can be expected to find expanding use in mycotoxin analysis.

Keywords

LC–MS–MS Mycotoxins Ochratoxin A Patulin Stable isotope dilution assay Trichothecenes 

References

  1. 1.
    Soddy F (1913) Nature 92:399–400CrossRefGoogle Scholar
  2. 2.
    Hevesy G, Paneth F (1913) Z Anorg Chem 82:323–328CrossRefGoogle Scholar
  3. 3.
    Aston FW (1919) Nature 104:334CrossRefGoogle Scholar
  4. 4.
    Boni RL, Simpson JT, Naritsin DB, Saito K, Markey SP (1994) Biol Mass Spectrom 23:27–32CrossRefGoogle Scholar
  5. 5.
    Price KR (1979) Biomed Mass Spectrom 6:573–574CrossRefGoogle Scholar
  6. 6.
    Jonckheere JA, Leenheer APD (1983) Anal Chem 55:153–155CrossRefGoogle Scholar
  7. 7.
    Sabot J-F, Pinatel H (1993) Analyst 118:831–834CrossRefGoogle Scholar
  8. 8.
    Fay LB, Metairon S, Baumgartner M (2001) Flavour Fragr J 16:164–168CrossRefGoogle Scholar
  9. 9.
    Bretz M, Beyer M, Cramer B, Humpf H-U (2006) Mol Nutr Food Res 50:251–260CrossRefGoogle Scholar
  10. 10.
    Moss MO, Thrane U (2004) Toxicol Lett 153:23–28CrossRefGoogle Scholar
  11. 11.
    Schrodter R (2004) Toxicol Lett 153:47–49CrossRefGoogle Scholar
  12. 12.
    Ueno Y, Nakajima M, Sakai K, Ishii K, Sato N, Shimada N (1973) J Biochem 74:285–296Google Scholar
  13. 13.
    Schollenberger M, Muller H-M, Rufle M, Suchy S, Planck S, Drochner W (2005) Int J Food Microbiol 97:317–326CrossRefGoogle Scholar
  14. 14.
    Pawlosky RJ, Mirocha CJ, Wen Y, Abbas HK (1989) J Assoc Off Anal Chem 72:807–812Google Scholar
  15. 15.
    Razzazi-Fazeli E, Rabus B, Cecon B, Bohm J (2002) J Chromatogr A 968:129–142CrossRefGoogle Scholar
  16. 16.
    Asam S, Rychlik M (2006) J Agric Food Chem 54:6535–6546CrossRefGoogle Scholar
  17. 17.
    Hädrich J, Vogelgesang J (1999) Dtsch Lebensm Rundsch 95:428–436Google Scholar
  18. 18.
    Bretz M, Beyer M, Cramer B, Humpf H-U (2005) Mol Nutr Food Res 49:1151–1153CrossRefGoogle Scholar
  19. 19.
    Häubl G, Berthiller F, Rechthaler J, Jaunecker G, Binder EM, Krska R, Schuhmacher R (2006) Food Addit Contam 23:1187–1193CrossRefGoogle Scholar
  20. 20.
    Häubl G, Berthiller F, Krska R, Schuhmacher R (2006) Anal Bioanal Chem 384:692–696CrossRefGoogle Scholar
  21. 21.
    Asam S, Rychlik M (2006) Eur Food Res Technol 224:769–783CrossRefGoogle Scholar
  22. 22.
    Shier WT, Shier AC, Xie W, Mirocha CJ (2001) Toxicon 39:1435–1438CrossRefGoogle Scholar
  23. 23.
    Munoz L, Riguera R (1990) Magn Reson Chem 28:665–667CrossRefGoogle Scholar
  24. 24.
    Miles CO, Erasmuson AF, Wilkins AL, Towers NR, Smith BL, Garthwaite I, Scahill BG, Hansen RP (1996) J Agric Food Chem 44:3244–3250CrossRefGoogle Scholar
  25. 25.
    Zoellner P, Jodlbauer J, Kleinova M, Kahlbacher H, Kuhn T, Hochsteiner W, Lindner W (2002) J Agric Food Chem 50:2494–2501CrossRefGoogle Scholar
  26. 26.
    Songsermsakul P, Sontag G, Cichna-Markl M, Zentek J, Razzazi-Fazeli E (2006) J Chromatogr B 843:252–261CrossRefGoogle Scholar
  27. 27.
    Launay FM, Young PB, Sterk SS, Blokland MH, Kennedy DG (2004) Food Addit Contam 21:52–62CrossRefGoogle Scholar
  28. 28.
    Hartmann N, Erbs M, Wettstein FE, Schwarzenbach RP, Bucheli TD (2007) J Chromatogr A 1138:132–140CrossRefGoogle Scholar
  29. 29.
    Sforza S, Dall'Asta C, Moseriti A, Galaverna G, Dossena A, Marchelli R (2005) Angew Chem Int Ed 44:5126–5130CrossRefGoogle Scholar
  30. 30.
    Marasas WFO (2001) Environ Health Perspect Suppl 109:239–243CrossRefGoogle Scholar
  31. 31.
    Marasas WFO, Riley RT, Hendricks KA, Stevens VL, Sadler TW, Gelineau-van Waes J, Missmer SA, Cabrera J, Torres O, Gelderblom WCA, Allegood J, Martinez C, Maddox J, Miller JD, Starr L, Sullards MC, Roman AV, Voss KA, Wang E, Merrill AHJ (2004) J Nutr 134:711–716Google Scholar
  32. 32.
    Plattner RD, Shackelford DD (1992) Mycopathologia 117:17–22CrossRefGoogle Scholar
  33. 33.
    Plattner RD, Branham BE (1994) JAOAC Int 77:525–532Google Scholar
  34. 34.
    Lukacs Z, Schaper S, Herderich M, Schreier P, Humpf H-U (1996) Chromatographia 43:124–128CrossRefGoogle Scholar
  35. 35.
    Hartl M, Herderich M, Humpf HU (1999) Eur Food Res Technol 209:348–351CrossRefGoogle Scholar
  36. 36.
    Hartl M, Humpf HU (1999) J Agric Food Chem 47:5078–5083CrossRefGoogle Scholar
  37. 37.
    Seefelder W, Hartl M, Humpf H-U (2001) J Agric Food Chem 49:2146–2151CrossRefGoogle Scholar
  38. 38.
    Seefelder W, Gossmann M, Humpf H-U (2002) J Agric Food Chem 50:2778–2781CrossRefGoogle Scholar
  39. 39.
    Becci PJ, Hess FG, Johnson WD, Gallo MA, Babish JG, Dailey RE, Parent RA (1981) J Appl Toxicol 1:256–261CrossRefGoogle Scholar
  40. 40.
    Dickens F, Jones HEH (1961) Br J Cancer 15:85–100Google Scholar
  41. 41.
    AOAC (1997) Official Methods of Analysis of AOAC International 16th edn. AOAC International; Gaithersburg, Maryland, Method 995.10Google Scholar
  42. 42.
    Sewram V, Nair JJ, Nieuwoudt TW, Leggott NL, Shephard GS (2000) J Chromatogr A 897:365–374CrossRefGoogle Scholar
  43. 43.
    Takino M, Daishima S, Nakahara T (2003) Rapid Commun Mass Spectrom 17:1965–1972CrossRefGoogle Scholar
  44. 44.
    Roach JAG, White KD, Trucksess MW, Thomas FS (2000) J AOAC Int 83:104–112Google Scholar
  45. 45.
    Ralls JW, Lane RM (1977) J Food Sci 42:1117–1119CrossRefGoogle Scholar
  46. 46.
    Suzuki T, Fujimoto Y, Hoshino Y, Tanaka A (1974) Agric Biol Chem 38:1259–1260Google Scholar
  47. 47.
    Tarter EJ, Scott PM (1991) J Chromatography 538:441–446CrossRefGoogle Scholar
  48. 48.
    Rychlik M, Schieberle P (1998) J Agric Food Chem 46:5163–5169CrossRefGoogle Scholar
  49. 49.
    Rychlik M, Schieberle P (1999) J Agric Food Chem 47:3749–3755CrossRefGoogle Scholar
  50. 50.
    Ito R, Yamazaki H, Inoue K, Yoshimura Y, Kawaguchi M, Nakazawa H (2004) J Agric Food Chem 52:7464–7468CrossRefGoogle Scholar
  51. 51.
    Coring systems, http:www.coring.de
  52. 52.
    Osswald H, Frank HK, Komitowski D, Winter H (1978) Food Cosmet Toxicol 16:243–247CrossRefGoogle Scholar
  53. 53.
    Rychlik M, Kircher F, Schusdziarra V, Lippl F (2004) Food Chem Toxicol 42:729–735CrossRefGoogle Scholar
  54. 54.
    Rychlik M (2003) Food Addit Contam 20:829–837CrossRefGoogle Scholar
  55. 55.
    Fliege R, Metzler M (2000) Chem Res Toxicol 13:373–381CrossRefGoogle Scholar
  56. 56.
    Rychlik M (2005) Ernaehrung 29:61–68Google Scholar
  57. 57.
    Kuiper-Goodman T, Scott PM (1989) Biomed Environ Sci 2:179–248Google Scholar
  58. 58.
    Hult K, Plestina R, Habazin-Novak V, Radic B, Ceovic S (1982) Arch Toxicol 51:313–321CrossRefGoogle Scholar
  59. 59.
    EC directive (2006) 1881/2006Google Scholar
  60. 60.
    Märtlbauer E, Terplan G (1988) Arch Lebensm Hyg 39:133–156Google Scholar
  61. 61.
    Losito I, Monaci L, Palmisano F, Tantillo G (2004) Rap Commun Mass Spectrom 18:1965–1971CrossRefGoogle Scholar
  62. 62.
    Goryacheva IY, De Saeger S, Lobeau M, Eremin SA, Barna-Vetro I, Van Peteghem C (2006) Anal Chim Acta 577:38–45CrossRefGoogle Scholar
  63. 63.
    Reinsch M, Toepfer A, Lehmann A, Nehls I, Panne U (2006) Food Chem 100:312–317CrossRefGoogle Scholar
  64. 64.
    Jorgensen K, Vahl M (1999) Food Addit Contam 16:451–456CrossRefGoogle Scholar
  65. 65.
    Lindenmeier M, Schieberle P, Rychlik M (2004) J Chromatogr A 1023:57–66CrossRefGoogle Scholar
  66. 66.
    Biopure reference compounds, http:www.biopure.at
  67. 67.
    Sulyok M, Berthiller F, Krska R, Schuhmacher R (2006) Rap Commun Mass Spectrom 20:2649–2659CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Lehrstuhl für Lebensmittelchemie der TechnischenUniversität MünchenGarchingGermany

Personalised recommendations