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Analytical and Bioanalytical Chemistry

, Volume 390, Issue 1, pp 239–243 | Cite as

Scanning force microscopy based amperometric biosensors

  • Christine KranzEmail author
  • Justyna Wiedemair
Trends

Introduction

Cantilever-based biosensing has developed into an important research area especially for biomedical and clinical analysis. In particular, the possibility to scan miniaturized amperometric biosensors with high-fidelity distance control across biomedically relevant sample surfaces enables the determination of pertinent analytes such as, e.g., adenosine 5′-triphosphate (ATP). ATP is involved in a wide variety of important regulatory cellular mechanisms, and quantification of ATP has therefore been the focus of extensive research in recent years.

Usually, scanning force microscopy-based biosensing relates to detection principles based on either mass-sensitive mechanical transduction, which can be detected as a frequency change of the cantilever, or a change in the force constant due to the absorption of molecules onto the sensor surface, as shown in Fig.  1a. Alternatively, a bimetallic cantilever can be used as a temperature sensing device for detecting calorimetric changes...

Keywords

Atomic Force Microscopy Atomic Force Microscopy Probe Amperometric Biosensor Scan Force Microscopy Unmodified Electrode 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.School of Chemistry and BiochemistryGeorgia Institute of TechnologyAtlantaUSA

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