Recent applications of near-infrared spectroscopy in cancer diagnosis and therapy

  • Venkata Radhakrishna Kondepati
  • H. Michael Heise
  • Juergen Backhaus
Review
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Abstract

In recent years, near-infrared spectroscopy (NIRS) has gained importance for non-invasive or minimally invasive diagnostic applications in cancer. This technology is based on differences of endogenous chromophores between cancer and normal tissues using either oxy-haemoglobin or deoxy-haemoglobin, lipid or water bands, or a combination of two or more of these as diagnostic markers. These marker bands provide a basis for the diagnosis and therapy monitoring of several cancers. Various applications also use advances in NIR fluorescence spectroscopy which is based on exogenous contrast-enhancing agents. In this review the literature published during the last seven years has been assessed. It will provide an overview on the importance of the NIRS tools in cancer pathology, and in the near future it is envisaged to play a crucial role in cancer diagnosis, treatment decisions, and defining therapeutic drug levels.

Keywords

Near-infrared spectroscopy Cancer diagnosis Therapy monitoring 
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Notes

Acknowledgements

The authors from ISAS are grateful for continued financial support by the Ministerium für Innovation, Wissenschaft, Forschung und Technologie des Landes NRW and the Bundesministerium für Bildung und Forschung (BMBF).

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Venkata Radhakrishna Kondepati
    • 1
  • H. Michael Heise
    • 1
  • Juergen Backhaus
    • 2
  1. 1.ISAS – Institute for Analytical Sciences at the University of DortmundDortmundGermany
  2. 2.Institute for Instrumental Analysis and BioanalysisMannheim University of Applied SciencesMannheimGermany

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