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Analytical and Bioanalytical Chemistry

, Volume 390, Issue 1, pp 3–16 | Cite as

Elemental mass spectrometry for quantitative proteomics

  • Alfredo Sanz-MedelEmail author
  • María Montes-Bayón
  • María del Rosario Fernández de la Campa
  • Jorge Ruiz Encinar
  • Jörg Bettmer
Review

Abstract

In the last decade mass-spectrometry-based proteomics has become an indispensable analytical tool for molecular biology, cellular biology and, lately, for the emerging systems biology. This review summarises the evolution and great potential of analytical methods based on elemental mass-spectrometric detection for quantitative proteomic analysis.

Keywords

Bioanalytical methods Genomics/Proteomics Mass spectrometry/Inductively coupled plasma mass spectrometry Speciation 

Abbreviations

2D

two-dimensional

AFP

α-Fetoprotein

CE

capillary electrophoresis

ESI

electrospray ionisation

GE

gel electrophoresis

HPLC

high-performance liquid chromatography

ICAT

isotope-coded affinity tags

ICP

inductively coupled plasma

IDA

isotope dilution analysis

IgG

immunoglobulin G

LA

laser ablation

LC

liquid chromatography

μLC

capillary liquid chromatography

MALDI

matrix-assisted laser desorption and ionisation

MS

mass spectrometry

MT

metallothionein

SEC

size-exclusion chromatography

SILAC

stable isotope labelling by amino acids in cell cultures

SFMS

sector field mass spectrometry

T3

triiodothyronine

T4

thyroxine

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Alfredo Sanz-Medel
    • 1
    Email author
  • María Montes-Bayón
    • 1
  • María del Rosario Fernández de la Campa
    • 1
  • Jorge Ruiz Encinar
    • 1
  • Jörg Bettmer
    • 1
  1. 1.Department of Physical and Analytical Chemistry, Faculty of ChemistryUniversity of OviedoOviedoSpain

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