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Analytical and Bioanalytical Chemistry

, Volume 389, Issue 2, pp 455–460 | Cite as

Application of the Doehlert experimental design to molecularly imprinted polymers: surface response optimization of specific template recognition as a function of the type and degree of cross-linking

  • Claire Rossi
  • Karsten HauptEmail author
Technical Note

Abstract

We propose the use of Doehlert’s experimental design, a second-order uniform shell design, for the optimization of molecularly imprinted polymers (MIPs). We have chosen a simple model system where the influence of kind and degree of cross-linking on template recognition was studied using S-propranolol as the template. We found that Doehlert’s design allows—with very few experiments—one to screen the evolution of the binding capacity of a MIP as a function the different parameters, and thus appears to be a powerful means to screen for the best composition and synthesis method for MIPs. We believe that this chemometric tool can significantly accelerate the development of new MIPs as synthetic recognition elements, particularly in the context of a given application, and will be a versatile complement or alternative to first-order designs to fit complex processes.

Keywords

Chemometrics Statistics Molecularly imprinted polymers (MIP) Polymers 

Supplementary material

216_2007_1484_MOESM1_ESM.pdf (63 kb)
ESM 1 Application of the Doehlert experimental design to molecularly imprinted polymers: surface response optimization of specific template recognition as a function of the type and degree of cross-linking. (PDF 64 kb)

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.UMR CNRS 6022 - Centre de Recherches de RoyallieuCompiègne University of TechnologyCompiègne cedexFrance

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