Analytical and Bioanalytical Chemistry

, Volume 389, Issue 2, pp 377–397 | Cite as

Chiral recognition applications of molecularly imprinted polymers: a critical review

  • Norbert M. MaierEmail author
  • Wolfgang Lindner


Molecular imprinting technology offers the unique opportunity to tailor chiral stationary phases with predefined chiral recognition properties by employing the enantiomers of interest as binding-site-forming templates. Added advantages, such as ease of preparation, chemical robustness, low-cost production, and the possibility of shaping molecularly imprinted polymers (MIPs) in various self-supporting formats, render them attractive materials for a broad range of chiral recognition applications. In this review a critical overview on recent developments in the field of MIP-based chiral recognition applications is given, focusing on separation techniques and molecular sensing. Inherent limitations associated with the use of enantioselective MIP materials in high-performance separation techniques are outlined, including binding site heterogeneity and slow mass transfer characteristics. The prospects of MIP materials as versatile recognition elements for the design of enantioselective sensor systems are highlighted.


Molecular imprinting technology Chiral recognition Enantiomer separation Liquid chromatography Membrane separation Batch extraction Sensors 



acetic acid


acidic glycoprotein




aspartic acid


tert-butylcarboxycarbonyl protecting group


saturation loading capacity


capillary electrochromatography


chiral stationary phase




ethylene dimethacrylate


electroosmotic flow


9-Fluorenylmethoxycarbonyl protecting group


glutamic acid


high-performance liquid chromatography


indium tin oxide


ion-selective field-effect transistor


dissociation constants


potentiometric selectivity coefficient


methacrylic acid




molecularly imprinted polymer


non-imprinted control polymer




open tubular




phenylalanine anilide


phosphate-buffered saline


pentaerythritol triacrylate




quartz-crystal microbalance


reversible addition–fragmentation chain transfer


reflectometric interference spectroscopy


surface acoustic wave


supercritical-fluid chromatography


simulated moving bed






2,2-bis(hydroxymethyl)butanol trimethacrylate






benzyloxycarbonyl protecting group


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© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Department of Analytical Chemistry and Food ChemistryUniversity of ViennaViennaAustria

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