Analytical and Bioanalytical Chemistry

, Volume 388, Issue 7, pp 1365–1380 | Cite as

New analytical strategies in studying drug metabolism

Review

Abstract

Identification and elucidation of the structures of metabolites play major roles in drug discovery and in the development of pharmaceutical compounds. These studies are also important in toxicology or doping control with either pharmaceuticals or illicit drugs. This review focuses on: new analytical strategies used to identify potential metabolites in biological matrices with and without radiolabeled drugs; use of software for metabolite profiling; interpretation of product spectra; profiling of reactive metabolites; development of new approaches for generation of metabolites; and detection of metabolites with increased sensitivity and simplicity. Most of the new strategies involve mass spectrometry (MS) combined with liquid chromatography (LC).

Keywords

Liquid chromatography Mass spectrometry Drug metabolism 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  1. 1.Life Sciences Mass Spectrometry, School of Pharmaceutical SciencesUniversity of Geneva, University of LausanneGenève 4Switzerland

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