Analytical and Bioanalytical Chemistry

, Volume 387, Issue 2, pp 533–537

Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model

  • Michael S. Hodavance
  • Sarah L. Ralston
  • István Pelczer
Review

DOI: 10.1007/s00216-006-0979-z

Cite this article as:
Hodavance, M.S., Ralston, S.L. & Pelczer, I. Anal Bioanal Chem (2007) 387: 533. doi:10.1007/s00216-006-0979-z

Abstract

Metabonomic analysis is a powerful tool for identifying and characterizing metabolic disorders, for example type 2 diabetes and the metabolic syndrome. Nuclear magnetic resonance (NMR) spectroscopy is an essential tool for such analysis, with special benefits. The review assesses the current status and potential of NMR-based metabonomics of type 2 diabetes. The horse is proposed as a possible model for studying this condition and disease. Some examples are shown of horse blood analyses by NMR.

Keywords

Metabonomics Type 2 diabetes Horses Glucose tolerance Insulin resistance NMR 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Michael S. Hodavance
    • 1
  • Sarah L. Ralston
    • 2
  • István Pelczer
    • 1
  1. 1.Department of ChemistryPrinceton UniversityPrincetonUSA
  2. 2.Department of Animal Science, School of Environmental and Biological Sciences, RutgersThe State University of New JerseyNew BrunswickUSA

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