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Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model

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Abstract

Metabonomic analysis is a powerful tool for identifying and characterizing metabolic disorders, for example type 2 diabetes and the metabolic syndrome. Nuclear magnetic resonance (NMR) spectroscopy is an essential tool for such analysis, with special benefits. The review assesses the current status and potential of NMR-based metabonomics of type 2 diabetes. The horse is proposed as a possible model for studying this condition and disease. Some examples are shown of horse blood analyses by NMR.

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Acknowledgements

The authors are thankful to Bruker–Biospin, Co. (Billerica, MA, USA) for providing access to essential instrumentation. Dr Robert Krull (Bruker–Biospin) provided essential help acquiring the 13C NMR spectra. M.S.H. received financial support from Wyeth Research. Additional support from Princeton University is greatly appreciated. Isotec (Stable Isotope Products: A Sigma–Aldrich Company, St Louis, MO, USA) kindly donated a substantial amount of the [U-13C]-labeled glucose. Useful discussions with Dr Richard Barton (Imperial College, London, UK) are truly appreciated.

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Authors and Affiliations

  1. Department of Chemistry, Princeton University, Princeton, NJ, 08544, USA

    Michael S. Hodavance & István Pelczer

  2. Department of Animal Science, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08981, USA

    Sarah L. Ralston

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  1. Michael S. Hodavance
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  2. Sarah L. Ralston
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  3. István Pelczer
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Correspondence to István Pelczer.

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Hodavance, M.S., Ralston, S.L. & Pelczer, I. Beyond blood sugar: the potential of NMR-based metabonomics for type 2 human diabetes, and the horse as a possible model. Anal Bioanal Chem 387, 533–537 (2007). https://doi.org/10.1007/s00216-006-0979-z

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  • DOI: https://doi.org/10.1007/s00216-006-0979-z

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