Analytical and Bioanalytical Chemistry

, Volume 387, Issue 4, pp 1167–1172 | Cite as

Trends in human risk assessment of pharmaceuticals

  • J. L. C. M. Dorne
  • A. M. J. Ragas
  • G. K. Frampton
  • D. S. Spurgeon
  • D. F. Lewis
Trends

Notes

Acknowledgements

This manuscript is dedicated to the memory of Professor John Theobald (1946–2006).

Some of the authors (JLCMD, AMJR, DSS) are grateful to the European Commission under the NOMIRACLE project (number 003956) for funding this work. The opinions reflected in this review are the authors’ only.

References

  1. 1.
    Ashton D, Hilton M, Thomas KV (2004) Sci Total Environ 333:167–184CrossRefGoogle Scholar
  2. 2.
    Corvi R, Ahr HJ, Albertini S, Blakey DH, Clerici L, Coecke S, Douglas GR, Gribaldo L, Groten JP, Haase B, Hamernik K, Hartung T, Inoue T, Indans I, Maurici D, Orphanides G, Rembges D, Sansone SA, Snape JR, Toda E, Tong W, van Delft JH, Weis B, Schechtman LM (2006) Environ Health Perspect 114:420–429CrossRefGoogle Scholar
  3. 3.
    Crane M, Watts C, Boucard T (2006) Sci Total Environ 367:23-41CrossRefGoogle Scholar
  4. 4.
    Christensen FM (1998) Regul Toxicol Pharmacol 28:212–221CrossRefGoogle Scholar
  5. 5.
    Cullen AC, Frey HC (1999) Probabilistic techniques in exposure assessment. A handbook for dealing with variability and uncertainty in models and inputs. Society for risk analysis. Plenum Press, New York, United StatesGoogle Scholar
  6. 6.
    Di Consiglio E, Meneguz A, Testai E (2005) Toxicol. Appl. Pharmacol. 205:237-246CrossRefGoogle Scholar
  7. 7.
    Dorne JLCM, Renwick AG (2003) Toxicol Lett 144:S195CrossRefGoogle Scholar
  8. 8.
    Dorne JL, Walton K, Renwick AG (2005) Food Chem Toxicol 43:203–216CrossRefGoogle Scholar
  9. 9.
    Dorne JL, Renwick AG (2005) Toxicol Sci 86:20–26CrossRefGoogle Scholar
  10. 10.
    Dorne JLCM, Skinner L, Frampton G, Spurgeon D, Ragas A (2006) Anal Bioanal Chem (This issue)Google Scholar
  11. 11.
    Dorne JLCM (2006) J Appl Toxicol (in press)Google Scholar
  12. 12.
    Dorne JLCM, Papadopoulos A (2006) Proceedings of SETAC EUROPE 2006. The Hague, The Netherlands –AbstractGoogle Scholar
  13. 13.
    Fent K, Weston AA, Caminada D (2006) Aquat. Toxicol. 76:122–159CrossRefGoogle Scholar
  14. 14.
    Hodgson E, Rose RL (2005) Drug Metab Rev. 37:1–39CrossRefGoogle Scholar
  15. 15.
    Jones OA, Lester JN, Voulvoulis N (2005) Trends Biotechnol 23:163–167CrossRefGoogle Scholar
  16. 16.
    Lewis DF (2004) Sci World J 4:1074–1082Google Scholar
  17. 17.
    Lewis DF, Lake BG, Dickins M (2006) J Enzyme Inhib Med Chem 21:127–132CrossRefGoogle Scholar
  18. 18.
    Matthews EJ, Kruhlak NL, Benz RD, Contrera JF (2004) Curr Drug Discov Technol 1:61–76CrossRefGoogle Scholar
  19. 19.
    Moe CL, Rheingans RD (2006) J. Water Health 4 Suppl 1:41–57Google Scholar
  20. 20.
    Perkins R, Fang H, Tong W, Welsh WJ (2003) Environ Toxicol Chem 22:1666–1679CrossRefGoogle Scholar
  21. 21.
    Potera C (2000) Environ Health Perspect 108:A446CrossRefGoogle Scholar
  22. 22.
    Roelofs W, Huijbregts, MAJ, Jager T, Ragas AMJ (2003) Environ Toxicol Chem 22:1387–1393CrossRefGoogle Scholar
  23. 23.
    Ragas AMJ, Huijbregts MAJ (1998) Reg Toxicol Pharmacol 27:251–264CrossRefGoogle Scholar
  24. 24.
    Renwick AG (1993) Food Addit. Contam 10:275–305Google Scholar
  25. 25.
    Schulman LJ, Sargent EV, Naumann BD, Faria EC, Dolan DG, Wargo JP (2002) Human Ecol Risk Assess 8:657–680CrossRefGoogle Scholar
  26. 26.
    Schwab BW, Hayes EP, Fiori JM, Mastrocco FJ, Roden NM, Cragin D, Meyerhoff RD, D’Aco VJ, Anderson PD (2005) Regul Toxicol Pharmacol 42:296–312CrossRefGoogle Scholar
  27. 27.
    Seiler JP (2002) Toxicol Lett 131:105–115CrossRefGoogle Scholar
  28. 28.
    Van Leeuwen FX (2000) Food Chem Toxicol 38:S51–S58CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • J. L. C. M. Dorne
    • 1
  • A. M. J. Ragas
    • 2
  • G. K. Frampton
    • 3
  • D. S. Spurgeon
    • 4
  • D. F. Lewis
    • 5
  1. 1.Clinical Pharmacology Group,Division of Developmental Origins of Health and Disease, Institute of Human NutritionSchool of MedicineSouthamptonUK
  2. 2.Department of Environmental Science, Institute for Wetland & Water Research,Faculty of ScienceRadboud University NijmegenNijmegenThe Netherlands
  3. 3.Ecology and Evolutionary Biology GroupUniversity of SouthamptonSouthamptonUK
  4. 4.Centre for Ecology and HydrologyHuntington, CambridgeshireUK
  5. 5.School of Biomedical and Molecular SciencesUniversity of SurreyGuildfordUK

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