Analytical and Bioanalytical Chemistry

, Volume 387, Issue 2, pp 551–559

Combined Fourier-transform infrared imaging and desorption electrospray-ionization linear ion-trap mass spectrometry for analysis of counterfeit antimalarial tablets

  • Camilla Ricci
  • Leonard Nyadong
  • Facundo M. Fernandez
  • Paul N. Newton
  • Sergei G. Kazarian
Original Paper

Abstract

This paper reports use of a combination of Fourier-transform infrared (FTIR) spectroscopic imaging and desorption electrospray ionization linear ion-trap mass spectrometry (DESI MS) for characterization of counterfeit pharmaceutical tablets. The counterfeit artesunate antimalarial tablets were analyzed by both techniques. The results obtained revealed the ability of FTIR imaging in non-destructive micro-attenuated total reflection (ATR) mode to detect the distribution of all components in the tablet, the identities of which were confirmed by DESI MS. Chemical images of the tablets were obtained with high spatial resolution. The FTIR spectroscopic imaging method affords inherent chemical specificity with rapid acquisition of data. DESI MS enables high-sensitivity detection of trace organic compounds. Combination of these two orthogonal surface-characterization methods has great potential for detection and analysis of counterfeit tablets in the open air and without sample preparation.

Keywords

Fake drugs Malaria Chemical imaging Mass spectrometry Forensic Artesunate 

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Camilla Ricci
    • 1
  • Leonard Nyadong
    • 2
  • Facundo M. Fernandez
    • 2
  • Paul N. Newton
    • 3
    • 4
  • Sergei G. Kazarian
    • 1
  1. 1.Department of Chemical EngineeringImperial College LondonLondonUK
  2. 2.School of Chemistry and BiochemistryGeorgia Institute of TechnologyAtlantaUSA
  3. 3.Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration, Microbiology LaboratoryMahosot HospitalVientianeLaos
  4. 4.Centre for Clinical Vaccinology and Tropical Medicine, Churchill HospitalOxford UniversityOxfordUK

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