Analytical and Bioanalytical Chemistry

, Volume 387, Issue 2, pp 381–390

New insights into the regulatory mechanisms of the LuxR family of quorum sensing regulators


DOI: 10.1007/s00216-006-0702-0

Cite this article as:
Nasser, W. & Reverchon, S. Anal Bioanal Chem (2007) 387: 381. doi:10.1007/s00216-006-0702-0


Bacteria use small signal molecules, referred to as autoinducers, in order to monitor their population density and coordinate gene expression in a process named quorum sensing. In Gram-negative bacteria, acylated homoserine lactones are the most common autoinducer used for cell-to-cell communication. Increasing evidence that many different functions are controlled by acylated homoserine lactone quorum sensing has stimulated intensive investigations into the physiology, molecular biology and biochemistry that underlie this process. Here we review our current understanding of the molecular mechanisms used by the transcriptional regulators responsive to acylated homoserine lactone autoinducers to control gene expression and the structural modifications induced by acylated homoserine lactones binding specifically on these regulators.


Quorum sensing Cell population density Bacterial autoinducer Acylated homoserine lactone LuxR Transcriptional regulation Enzymes Pharmaceuticals Nucleic acids (DNA|RNA) 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Unité de Microbiologie et GénétiqueUMR CNRS-INSA-Université Lyon 1 5122Villeurbanne CedexFrance

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