Analytical and Bioanalytical Chemistry

, Volume 386, Issue 5, pp 1201–1214 | Cite as

New chromogenic and fluorogenic reagents and sensors for neutral and ionic analytes based on covalent bond formation–a review of recent developments

  • Gerhard J. Mohr


To date, hydrogen bonding and Coulomb, van der Waals and hydrophobic interactions are the major contributors to non-covalent analyte recognition using ionophores, ligands, aptamers and chemosensors. However, this article describes recent developments in the use of (reversible) covalent bond formation to detect analyte molecules, with special focus on optical signal transduction. Several new indicator dyes for analytes such as amines and diamines, amino acids, cyanide, formaldehyde, hydrogen peroxide, organophosphates, nitrogen oxide and nitrite, peptides and proteins, as well as saccharides have become available. New means of converting analyte recognition into optical signals have also been introduced, such as colour changes of chiral nematic layers. This article gives an overview of recent developments and discusses response mechanisms, selectivity and sensitivity.


Chemosensor Optical probe Optical sensor Biomolecules Chemical warfare agents 



This work was supported by the Heisenberg Fellowship MO 1062/1-1 and research grant MO 1062/2-1 of Deutsche Forschungsgemeinschaft. This support is gratefully acknowledged.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Institute of Physical ChemistryFriedrich Schiller University of JenaJenaGermany

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