Analytical and Bioanalytical Chemistry

, Volume 384, Issue 3, pp 620–630

Nano-oncology: drug delivery, imaging, and sensing

Review

Abstract

Innovation in the last decade has endowed nanotechnology with an assortment of tools for delivery, imaging, and sensing in cancer research—stealthy nanoparticle vectors circulating in vivo, assembled with exquisite molecular control, capable of selective tumor targeting and potent delivery of therapeutics; intense and photostable quantum dot-based tumor imaging, enabling multicolor detection of cell receptors with a single optical excitation source; arrays of semiconducting nanowire and carbon nanotube sensor elements for selective multiplexed sensing of cancer markers without the need for probe labeling. These rapidly emerging tools are indicative of a burgeoning field ready to expand into medical applications. This review attempts to outline most of the current nanoparticle toolset for therapeutic release by liposomes, dendrimers, smart polymers, and virus-based systems. Advantages of nanoparticle-based imaging and targeting by use of nanoshells and quantum dots are also explored. Finally, emerging nanoelectronics-based sensing and a global discussion on the utility of each nanoparticle system addresses their fundamental advantages and shortcomings in cancer research.

Keywords

Nanotechnology Sensing Imaging Detection Cancer 

Abbreviations

CNT

Carbon nanotube

CPMV

Cowpea mosaic virus

DNA

Deoxyribonucleic acid

EPR

Enhanced permeability and retention

FHV

Flock-house virus

NW

Nanowire

ODN

Oligodeoxynucleotide

PEG

Poly(ethylene glycol)

QD

Quantum Dot

SWCNT

Single-walled carbon nanotube

References

  1. 1.
    Blume G, Cevec G (1990) Biochim Biophys Acta 1029:91–97CrossRefGoogle Scholar
  2. 2.
    Fenick DJ, Taatjes KJ, Koch TH (1997) J Med Chem 40:2452–2461CrossRefGoogle Scholar
  3. 3.
    Wold LE, Aberle NS, Ren J (2005) Cancer Detect Prev 29:294–299CrossRefGoogle Scholar
  4. 4.
    Laginha K, Mumbengegwi D, Allen T (2005) Biochim Biophys Acta 1711:25–32CrossRefGoogle Scholar
  5. 5.
    Ishida O, Maruyama K, Sasaki K, Iwatsuru M (1999) Int J Pharm 190:49–56CrossRefGoogle Scholar
  6. 6.
    Lasic, DD (1995) Applications of Liposomes. Handbook of Biological Physics Volume 1 Chapter 10, Elsevier Science B.V.Google Scholar
  7. 7.
    Fries LF, Gordon DM, Richards RL, Egan JE, Hollingdale MR, Gross M, Silverman C, Alving CR (1992) Proc Natl Acad Sci 89:358–362 ImmunologyCrossRefGoogle Scholar
  8. 8.
    Campos S (2003) Oncologist 8:10–16CrossRefGoogle Scholar
  9. 9.
    Needham D, Anyarambhatla G, Kong G, Dewhirst MW (2000) Cancer Res 60:1197–1201Google Scholar
  10. 10.
    Cascio A, di Martino L, Occorsio P, Giacchino R, Catania S, Gigliotti AR, Aiassa C, Iaria C, Giordano S, Colomba C, Polara VF, Titone L, Gradoni L, Gramiccia M, Antinori S (2004) J Antimicrob Chemother 54:217–220CrossRefGoogle Scholar
  11. 11.
    El-Sayed MEH, Hoffman AS, Stayton PS (2005) J Control Release 101:47–58CrossRefGoogle Scholar
  12. 12.
    Murthy N, Robichaud Jr, Tirrell DT, Stayton PS, Hoffman AS (1999) J Control Release 61:137–143CrossRefGoogle Scholar
  13. 13.
    Cheung CY, Murphy N, Stayton PS, Hoffman AS (2001) Bioconj Chem 12:906–910CrossRefGoogle Scholar
  14. 14.
    Boas U, Heegaard PMH (2004) Chem Soc Rev 33:43–63CrossRefGoogle Scholar
  15. 15.
    El Sayed M, Ginski M, Rhodes C, Ghandehari H (2002) J Control Release 81:355–365CrossRefGoogle Scholar
  16. 16.
    Malik N, Wiwattanapatapee R, Klopsch R, Lorenz K, Frey H, Weener JW, Meijer EW, Paulus W, Duncan R (2001) J Control Release 65:133–148CrossRefGoogle Scholar
  17. 17.
    Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW (2001) Magn Reson Med 46:781–788CrossRefGoogle Scholar
  18. 18.
    Luo D, Haverstick K, Belcheva N, Han E, Saltzman WM (2002) Macromolecules 35:3456–3462CrossRefGoogle Scholar
  19. 19.
    Gebhart CL, Kabanov AV (2001) J Control Release 73:401–416CrossRefGoogle Scholar
  20. 20.
    Kojima C, Kono K, Maruyama K, Takagishi T (2000) Bioconj Chem 11:910–917CrossRefGoogle Scholar
  21. 21.
    Gopidas KR, Whitesell JK, Fox MA (2003) J Am Chem Soc 125:6491–6502CrossRefGoogle Scholar
  22. 22.
    Gopidas KR, Whitesell JK, Fox MA (2003) Nano Lett 12:1757–1760CrossRefGoogle Scholar
  23. 23.
    Kirn D, Martuza RL, Zwiebel J (2001)Nat Med 7:781–787CrossRefGoogle Scholar
  24. 24.
    Roelvink PW, Lee GM, Einfeld DA, Kovesdi I, Wickham TJ (1999) Science 286:1568–1571CrossRefGoogle Scholar
  25. 25.
    Nemunaitis J, Khuri F, Ganly I, Arseneau J, Posner M, Vokes E, Kuhn J, McCarty T, Landers S, Blackburn A, Romel L, Randlev B, Kaye S, Kirn D (2001) J Clin Oncol 19:289–298Google Scholar
  26. 26.
    Todo T, Martuza RL, Rabkin SD, Johnson PA (2001) Proc Natl Acad Sci 98:6396–6401CrossRefGoogle Scholar
  27. 27.
    Kim E, Kim J, Shin H, Lee H, Yang JM, Kim J, Sohn J, Kim H, Yun C (2003) Hum Gene Ther 14:1415–1428CrossRefGoogle Scholar
  28. 28.
    Fisher AJ, Johnson JE (1993) Nature 361:176–179CrossRefGoogle Scholar
  29. 29.
    Fisher AJ, McKinney BR, Wery JP, Johnson JE (1992) Acta Crystallog B 48:515–520CrossRefGoogle Scholar
  30. 30.
    Wang Q, Lin T, Tang L, Johnson JE, Finn MG (2002) Angew Chem Int Edit 41:459–462CrossRefGoogle Scholar
  31. 31.
    Wang Q, Lin T, Johnson JE, Finn MG (2002) Chem Biol 9:813–819CrossRefGoogle Scholar
  32. 32.
    Wang Q, Kaltgrad E, Lin T, Johnson JE, Finn MG (2002) Chem Biol 9:805–811CrossRefGoogle Scholar
  33. 33.
    Lin T, Porta C, Lomonossoff G (1996) Fold Des 1:179–187CrossRefGoogle Scholar
  34. 34.
    Krishnaswami S (2003) Biomacromolecules 4:472–476CrossRefGoogle Scholar
  35. 35.
    Shenton W, Douglas T, Yong M, Stubbs G, Mann S (1999) Adv Mater 11:253–256CrossRefGoogle Scholar
  36. 36.
    Douglas T, Young M (1999) Adv Mater 11:679–681CrossRefGoogle Scholar
  37. 37.
    Portney NG, Singh K, Chaudhary S, Destito G, Schneemann A, Manchester M, Ozkan M (2005) Langmuir 21:2098–2103CrossRefGoogle Scholar
  38. 38.
    Kam NWS, Jessop TC, Wender PA, Dai H (2004) J Am Chem Soc 126:6850–6851CrossRefGoogle Scholar
  39. 39.
    Khorana HG (1993) Chem Rev 53:145CrossRefGoogle Scholar
  40. 40.
    Strable E, Johnson JE, Finn MG (2004) Nano Lett 4:1385–1389CrossRefGoogle Scholar
  41. 41.
    Lin E, Nemunaitis J (2004) Cancer Gene Ther 11:643–664CrossRefGoogle Scholar
  42. 42.
    Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M (2003) Science 302:415–419CrossRefGoogle Scholar
  43. 43.
    Holland J, Domingo E (1998) Virus Genes 16:13–21CrossRefGoogle Scholar
  44. 44.
    Lehrman S (1999) Nature 401:517CrossRefGoogle Scholar
  45. 45.
    Li Z, Dullmann J, Schiedlmeier B, Schmidt M, von Kalle C, Meyer J, Forster M, Stocking C, Wahlers A, Frank O, Ostertag W, Kuhlcke K, Eckert HG, Fehse B, Baum C (2002) Science 296:497CrossRefGoogle Scholar
  46. 46.
    Maeda H (2001) Adv Enzyme Regul 41:189–207CrossRefGoogle Scholar
  47. 47.
    Maeda H, Sawa T, Konno T (2001) J Control Release 74:47–61CrossRefGoogle Scholar
  48. 48.
    Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF (1983) Science 219:983–985CrossRefGoogle Scholar
  49. 49.
    O’Neal DP, Hirsch LR, Halas NJ, Payne JD, West JL (2004) Cancer Lett 209:171–176CrossRefGoogle Scholar
  50. 50.
    Green TR, Fisher J, Stone M, Wroblewski BM, Ingham E (1998) Biomaterials 19:2297–2302CrossRefGoogle Scholar
  51. 51.
    Moghimi SM, Hunter AC, Murray JC (2001) Pharmacol Rev 53:283–318Google Scholar
  52. 52.
    Hirsch LR, Stafford RJ, Bankson JA, Sershen SR, Rivera B, Price RE, Hazle JD, Halas NJ, West JL (2003) Proc Natl Acad Sci 100:13549–13554CrossRefGoogle Scholar
  53. 53.
    Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS, Hilditch TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J (1999) Clin Cancer Res 5:83–94Google Scholar
  54. 54.
    Hirsch LR, Jackson JB, Lee A, Halas NJ, West JL (2003) Anal Chem 75:2377–2381CrossRefGoogle Scholar
  55. 55.
    Seymour LW, Ferry DR, Anderson D, Hesslewood S, Julyan PJ, Poyner R, Doran J, Yong AM, Burtles S, Kerr DJ (2002) J Clin Oncol 20:1668–1676CrossRefGoogle Scholar
  56. 56.
    Oldenburg SJ, Jackson JB, Westcott SL, Halas NJ (1999) Appl Phys Lett 75:2897–2899CrossRefGoogle Scholar
  57. 57.
    Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S (2005) Science 307:534–544CrossRefGoogle Scholar
  58. 58.
    Zhang J (1997) Accounts Chem Res 30:432–429Google Scholar
  59. 59.
    Chan WCW, Nie S (1998) Science 281:2016–2018CrossRefGoogle Scholar
  60. 60.
    Ravindran S, Chaudhary S, Colburn B, Ozkan M, Ozkan CS (2003) Nano Lett 3:447–453CrossRefGoogle Scholar
  61. 61.
    Hermanson GT (1996) Bioconjugate Techniques. Academic PressGoogle Scholar
  62. 62.
    Wu X, Liu H, Liu J, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP (2003) Nat Biotechnol 21:41–46CrossRefGoogle Scholar
  63. 63.
    Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, Webb WW (2003) Science 300:1434–1436CrossRefGoogle Scholar
  64. 64.
    Kim JH, Morikis D, Ozkan M (2004) Sens Actuators B 102:315–319CrossRefGoogle Scholar
  65. 65.
    Medintz IL, Clapp AR, Mattoussi H, Goldman ER, Fisher B, Mauro JM (2003) Nat Mater 2:630–638CrossRefGoogle Scholar
  66. 66.
    Han M, Xiaohu, Su JZ, Nie S (2001) Nature 19:631–635CrossRefGoogle Scholar
  67. 67.
    Kim S, Lim YT, Soltesz EG, De Grand AM, Lee J, Nakayama A, Parker JA, Mihaljevic T, Laurence RG, Dor DM, Cohn LH, Bawendi MG, Frangioni JV (2004) Nat Biotechnol 22:93–97CrossRefGoogle Scholar
  68. 68.
    Lidke DS, Nagy P, Heintzmann R, Arndt-Jovin DJ, Post JN, Grecco HE, Jares-Erijman EA, Jovin TM (2004) Nat Biotechnol 22:198–203CrossRefGoogle Scholar
  69. 69.
    Yarden Y, Sliwkowski MX (2001) Nat Rev Mol Cell Biol 2:127–137CrossRefGoogle Scholar
  70. 70.
    Derfus AM, Chan WCW, Bhatia SN (2004) Nano Lett 4:11–18CrossRefGoogle Scholar
  71. 71.
    Kroto HW, Heath JR, O’Brien SC, Curl RF, Smalley RE (1985) Nature 318:162–163CrossRefGoogle Scholar
  72. 72.
    Iijima S (1991) Nature 254:56–58CrossRefGoogle Scholar
  73. 73.
    Morales AM, Lieber CM (1998) Science 279:208–211CrossRefGoogle Scholar
  74. 74.
    Star A, Gabriel JP, Bradley K, Gruner G (2003) Nano Lett 3:459–463CrossRefGoogle Scholar
  75. 75.
    Cui Y, Wei Q, Park H, Lieber CM (2001) Science 293:1289–1292CrossRefGoogle Scholar
  76. 76.
    Wong SS, Joselevich E, Woolley AT, Cheung CL, Lieber CM (1998) Nature 394:52–55CrossRefGoogle Scholar
  77. 77.
    Kong J, Franklin NR, Zhou C, Chapline MG, Peng S, Cho K, Dai H (2000) Science 287:622CrossRefGoogle Scholar
  78. 78.
    Patolsky F, Zheng G, Hayden O, Lakadamyali M, Zhuang X, Lieber CM (2004) Prc Natl Acad Sci 101:14017–14022CrossRefGoogle Scholar
  79. 79.
    Liu J, Rinzler AG, Dai H, Hafner JH, Bradley RK, Boul PJ, Lu A, Iverson T, Shelimov K, Huffman CB, Rodriguez-Macias F, Shon Y, Lee TR, Colbert D, Smalley RE (1998) Science 280:1253–1256CrossRefGoogle Scholar
  80. 80.
    Doorn SK, Strano MS, O’Connell MJ, Haroz EH, Rialon KL, Hauge RH, Smalley RE (2003) J Phys Chem B 107:6063–6069CrossRefGoogle Scholar
  81. 81.
    Chaudhary S, Kim JH, Singh KV, Ozkan, M (2004) Nano Lett 4:2415–2419CrossRefGoogle Scholar
  82. 82.
    Hirsch A (2002) Angew Chem Int Edit 41:1853–1859CrossRefGoogle Scholar
  83. 83.
    Wu G, Datar RH, Hansen KM, Thundat T, Cote RJ, Majumdar A (2001) Nat Biotechnol 19:856–860CrossRefGoogle Scholar
  84. 84.
    Cui D, Tian F, Ozkan CS, Wang M, Gao H (2005) Toxicol Lett 155:73–85CrossRefGoogle Scholar
  85. 85.
    Huajian Gao H, Kong Y, Cui D, Ozkan CS (2003) Nano Lett 3:471–473CrossRefGoogle Scholar
  86. 86.
    Cui D, Ozkan CS, Ravindran S, Kong Y, Gao H (2004) Mech Chem Biosyst 1:113–122Google Scholar
  87. 87.
    Emanuel F, Petricoin EF, Liotta LA (2004) Curr Opin Biotech 15:24–30CrossRefGoogle Scholar
  88. 88.
    Kukowska-Latallo JF, Candido KA, Cao Z, Nigavekar SS, Majoros IJ, Thomas TP, Balogh LP, Khan MK, Baker Jr JR (2005) Cancer Res 65:5317–5324CrossRefGoogle Scholar
  89. 89.
    Jiang Y, Emau P, Cairns JS, Flanary L, Morton WR, McCarthy TM, Tsai C (2005) AIDS Res Hum Retrov 21:207–213CrossRefGoogle Scholar
  90. 90.
    Godden-Kent D, Talbot SJ, Boshoff C, Chang Y, Moore P, Weiss RA, Mittnacht S (1997) J Virol 71:4193–4198Google Scholar
  91. 91.
    Moscardi F (1999) Annu Rev Entomol 44:257–289CrossRefGoogle Scholar
  92. 92.
    Loo C, Lowery A, Halas N, West J, Drezek R (2005) Nano Lett 5:709–711CrossRefGoogle Scholar
  93. 93.
    Rich Ornberg RL, Harper TF, Lui H (2005) Nat Methods 2:79–81CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Chemical and Environmental EngineeringUniversity of California, RiversideRiversideUSA
  2. 2.Department of Electrical EngineeringUniversity of California, RiversideRiversideUSA

Personalised recommendations