Analytical and Bioanalytical Chemistry

, Volume 384, Issue 1, pp 65–72 | Cite as

Enhancing the blood compatibility of ion-selective electrodes

  • Vasilis G. Gavalas
  • Maria J. Berrocal
  • Leonidas G. BachasEmail author


In vivo monitoring of various analytes is important for many bioanalytical and biomedical applications. The crucial challenge in this type of applications is the interaction of the sensor with the host environment, which is qualitatively described by the term biocompatibility. This review discusses recent advances in methods and materials used for the improvement of the biocompatibility of ion-selective electrodes especially as it relates to their interaction with blood components.


Ion-selective electrodes Biocompatibility Hemocompatibility Blood–membrane interactions 



The research described from the authors' laboratory has been funded by the National Science Foundation, the National Institutes of Health, and the National Aeronautics and Space Administration.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Vasilis G. Gavalas
    • 1
  • Maria J. Berrocal
    • 1
  • Leonidas G. Bachas
    • 1
    Email author
  1. 1.Department of Chemistry and Center of Membrane SciencesUniversity of KentuckyLexingtonUSA

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