Analytical and Bioanalytical Chemistry

, Volume 381, Issue 2, pp 397–404 | Cite as

Uses of speciation techniques in biomonitoring for assessing human exposure to organic environmental chemicals

  • Larry L. Needham
  • Donald G. PattersonJr.
  • Dana B. Barr
  • James Grainger
  • Antonia M. Calafat
Review

Abstract

Speciation analysis has been used for many years to identify and measure different forms of a given chemical in environmental and human samples. Although the term “speciation” is generally applied to the measurement of inorganic chemicals, the term can also be applied to many measurements of organic chemicals in complex samples, such as environmental media and biological matrices. We present several examples of achieving speciation analysis by selecting the appropriate biological matrix in which to measure a specific chemical(s), by a given analytical method, for the most accurate assessment of human exposure to the environmental chemical. Much of this information and many of these techniques are transferable to the measurement of inorganic elements in environmental and biological samples.

Keywords

Speciation Specificity Biomonitoring Chromatography Organic environmental chemicals 

References

  1. 1.
    Templeton DM, Ariese F, Cornelis R, Danielsson L-G, Muntau H, Van Leeuwen HP, Lobinski R (2000) Pure Appl Chem 72(8):1453–1470Google Scholar
  2. 2.
    Michalek JE, Pirkle JL, Caudill SP, Tripathi RC, Patterson DG, Needham LL (1996) J Toxicol Environ Health 47:209–220PubMedGoogle Scholar
  3. 3.
    Patterson DG, Needham LL, Pirkle JL, Roberts DW, Bagby J, Garrett WA, Andrews JS, Falk H, Bernert JT, Sampson EJ, Houk VN (1988) Arch Environ Contam Toxicol 17:139–143PubMedGoogle Scholar
  4. 4.
    Needham LL, Burse VW, Head SL, Korver MP, McClure PC, Andrews JS, Rowley DL, Sung J, Kahn SE (1990) Chemosphere 20:975–980Google Scholar
  5. 5.
    Bonin MA, Ashley DL, Cardinali FL, McCraw JM, Wooten JV (1995) J Anal Toxicol 19:187–191PubMedGoogle Scholar
  6. 6.
    Moolenaar RL, Hefflin BJ, Ashley DL, Middaugh JP, Etzel RA (1994) Arch Environ Health 49(5):402–409PubMedGoogle Scholar
  7. 7.
    Kuklenyik Z, Ekong J, Cutchins CD, Needham LL, Calafat AM (2003) Anal Chem 75:6820–6825CrossRefPubMedGoogle Scholar
  8. 8.
    Silva MJ, Malek N, Hodge CC, Reidy JA, Kato K, Barr DB, Needham LL, Brock JW (2003) J Chromatogr B 789:393–404Google Scholar
  9. 9.
  10. 10.
    Kato K, Silva MJ, Reidy JA, Hurtz III D, Malek NA, Calafat AM, Needham LL, Nakazawa H, Barr DB (2004) Environ Health Perspect 112(3):327–330PubMedGoogle Scholar
  11. 11.
    Barr D, Needham L (2002) J Chromatogr B 778:5–29CrossRefGoogle Scholar
  12. 12.
    Barr DB, Barr JR, Maggio VL, Whitehead RD, Sadowski MA, Whyatt RM, Needham LL (2002) J Chromatogr B 778:99–111Google Scholar
  13. 13.
    Patterson DG, Hampton L, Lapeza CRJ, Belser WT, Green V, Alexander L, Needham LL (1987) Anal Chem 59:2000–2005Google Scholar
  14. 14.
    Souverain S, Rudaz S, Veuthey J-L (2004) J Chromatogr B 801:141–156Google Scholar
  15. 15.
    Liu Z, Sirimanne SR, Patterson DG, Needham LL (1994) Anal Chem 66:3086–3092Google Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Larry L. Needham
    • 1
  • Donald G. PattersonJr.
    • 1
  • Dana B. Barr
    • 1
  • James Grainger
    • 1
  • Antonia M. Calafat
    • 1
  1. 1.Division of Laboratory SciencesNational Center for Environmental Health, Centers for Disease Control and PreventionAtlantaUSA

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