Analytical and Bioanalytical Chemistry

, Volume 379, Issue 7–8, pp 920–930 | Cite as

A unified view of propagating and localized surface plasmon resonance biosensors

  • Amanda J. Haes
  • Richard P. Van Duyne


The intense colors of noble metal nanoparticles have inspired artists and fascinated scientists for hundreds of years. In this review, we describe refractive index sensing platforms based on the tunability of the localized surface plasmon resonance (LSPR) of arrays of silver nanoparticles and of single nanoparticles. Specifically, the color associated with single nanoparticles and surface-confined nanoparticle arrays will be shown to be tunable and useful as platforms for chemical and biological sensing. Finally, the LSPR nanosensor will be compared to traditional, flat surface, propagating surface plasmon resonance sensors.


Localized surface plasmon resonance Nanosensor Single nanoparticle Spectroscopy Biosensing 



We acknowledge support of the Nanoscale Science and Engineering Initiative of the National Science Foundation under NSF Award Number EEC-0118025. Any opinions, findings and conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect those of the National Science Foundation. A.J. Haes also wishes to acknowledge the American Chemical Society Division of Analytical Chemistry and Dupont for a graduate fellowship. We are grateful for useful discussion and technical support provided by Adam McFarland.


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of Chemistry Northwestern UniversityEvanstonUSA

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