Molecularly imprinted polymers for solid-phase extraction
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Molecular recognition plays an important role in biological and chemical processes. Since molecular imprinting techniques can afford complementary binding site(s) for a target molecule, molecularly imprinted polymers (MIPs) have been used as chromatographic media, solid-phase extraction media, artificial antibodies, and sensors [1, 2, 3] for the specific recognition of target molecules. The use of MIPs in sample concentration, clean up, screening, and isolation by solid-phase extraction (SPE) with compound-specific or group-specific extractions are highly attractive and promising applications.
Two types of MIP formats, particle and membrane types, are available for use in SPE . Usually, the particle MIPs have been prepared by a non-aqueous bulk polymerization method, in which the resultant polymer rod had to be crushed, ground, and sieved to produce materials for SPE. To improve this tedious procedure, several new preparation methods for MIPs have emerged over the last decade. For...
KeywordsTarget Compound Functional Monomer Template Molecule Dispersion Polymerization Alprenolol
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