Analytical and Bioanalytical Chemistry

, Volume 378, Issue 8, pp 1944–1947 | Cite as

On-line LC-GC and comprehensive two-dimensional LCxGC-ToF MS for the analysis of complex samples

  • Hans-Gerd Janssen
  • Sjaak de Koning
  • Udo A. Th. Brinkman


Liquid chromatography (LC) and gas chromatography (GC) are by far the most frequently applied analytical methods in (organic) chemical analysis. To some extent LC and GC are competing techniques. With the exception of permanent gases, all analytes that can be separated using GC can also be subjected to LC. On the other hand, with the exception of high molecular-weight, highly polar or thermally labile analytes, many LC applications can also be handled by GC. Rather than considering the two chromatographic methods as competitors, hyphenated LC-GC exploits the complementary nature of LC and GC [1, 2]. LC has a high sample capacity and provides a wide range of separation mechanisms that can be utilized for selective isolation of (groups of) compounds. GC, on the other hand, offers a high separation efficiency as well as a wide variety of selective and sensitive detection devices. In LC-GC the compounds of interest are isolated from the complex matrix and are transferred...


PCBs Absolute Peak Area Liquid Chromatography Mode High Sample Capacity Comprehensive Liquid Chromatography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Grob K (2000) J Chromatogr A 892:407CrossRefPubMedGoogle Scholar
  2. 2.
    Hyötyläinen T, Riekkola M-L (2003) J Chromatogr A 1000:357CrossRefPubMedGoogle Scholar
  3. 3.
    van der Hoff GR, Hoogerbrugge R, Baumann RA, Brinkman UATh, van Zoonen P (2000) Chromatographia 52:433Google Scholar
  4. 4.
    Blomberg J, de Groot PC, Brandt HCA, van der Does JJB, Schoenmakers PJ (1999) J Chromatogr A 849:483CrossRefPubMedGoogle Scholar
  5. 5.
    Janssen H-G, Boers W, Steenbergen H, Horsten R, Flöter E (2003) J Chromatogr A 1000:385CrossRefPubMedGoogle Scholar
  6. 6.
    Bushey MM, Jorgenson JW (1990) Anal Chem 62:161Google Scholar
  7. 7.
    Phillips JB, Xu JZ (1995) J Chromatogr A 703:327CrossRefGoogle Scholar
  8. 8.
    de Koning S, Janssen H-G, van Deursen M, Brinkman UATh (2004) J Sep Sci (accepted)Google Scholar
  9. 9.
    Quigley WWC, Fraga CG, Synovec RE (2000) J Microcolumn Sep 12:160CrossRefGoogle Scholar
  10. 10.
    Reiter B, Lechner M, Lorbeer E, Aichholz R (1999) J High Res Chromatog 22:514CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Hans-Gerd Janssen
    • 1
  • Sjaak de Koning
    • 2
  • Udo A. Th. Brinkman
    • 3
  1. 1.Central Analytical ScienceUnilever Research and DevelopmentVlaardingenThe Netherlands
  2. 2.Separation Science GroupLECO Instrumente GmbHMönchengladbachGermany
  3. 3.Department of Analytical Chemistry and Applied SpectroscopyFree UniversityAmsterdamThe Netherlands

Personalised recommendations