Advertisement

Analytical and Bioanalytical Chemistry

, Volume 378, Issue 8, pp 1922–1928 | Cite as

Electrochemical sensing with electrodes modified with molecularly imprinted polymer films

  • M. C. Blanco-López
  • S. Gutiérrez-Fernández
  • M. J. Lobo-Castañón
  • A. J. Miranda-Ordieres
  • P. Tuñón-BlancoEmail author
Original Paper

Abstract

This article summarises our work on the development of voltammetric sensors based on molecularly imprinted polymers. Several recognition elements and integration strategies were used:
  1. 1.

    membranes electropolymerised at the electrode surface;

     
  2. 2.

    casting of polymeric membranes by drop-coating a solution of pre-formed polymer (polyphosphazene) and template in a low-boiling-point solvent on to the electrode surface;

     
  3. 3.

    preparation of composite membranes containing conductive material (graphite or carbon black), acrylic-type molecularly imprinted polymers (small particle size), and PVC as binder; and

     
  4. 4.

    in-situ polymerisation of a thin layer of acrylic imprinted polymer deposited on the electrode surface by spin coating.

     
All the options evaluated offer the possibility of controlling electrode characteristics such as hydrophobic/hydrophilic character, permeability, or film thickness, which are essential for obtaining good sensor performance.

Keywords

Molecularly imprinted polymers Voltammetric sensors Biomimetics 

Notes

Acknowledgements

Financial support from the Spanish government (Ministerio de Ciencia y Tecnología, project No. BQ-2002–00261) is acknowledged. S. Gutiérrez-Fernández thanks FICYT for a grant.

References

  1. 1.
    Piletsky S, Turner APF (2002) Electroanalysis 14:317–323CrossRefGoogle Scholar
  2. 2.
    Haupt K, Mosbach K (2000) Chem Rev 100:2495–2504CrossRefPubMedGoogle Scholar
  3. 3.
    Dickert FL, Hayden O (1999) Trends Anal Chem 18:192–198Google Scholar
  4. 4.
    Malitesta C, Losito I, Zambonin PG (1999) Anal Chem 71:1366–1370CrossRefGoogle Scholar
  5. 5.
    Peng H, Liang C, Zhou A, Zhang Y, Xie Q, Yao S (2000) Anal Chim Acta 423: 221–228CrossRefGoogle Scholar
  6. 6.
    Hutchins RS, Bachas LG (1995) Anal Chem 67:1654–1660Google Scholar
  7. 7.
    Panayuk T, Mirsky VM, Piletsky SA, Wolfbeis OS (1999) Anal Chem 71:4609–4613CrossRefGoogle Scholar
  8. 8.
    Spurlock LD, Jaramillo A, Praserthdam A, Lewis J, Brajter-Toth A (1996) Anal Chim Acta 336:37–46CrossRefGoogle Scholar
  9. 9.
    Panasyuk T, Campo V, Órto D, Marrazza G, El’skaya A, Piletsky S, Rezzano I, Mascini M (1998) Anal Lett 31:1809–1824Google Scholar
  10. 10.
    Gutiérrez-Fernández S, Lobo-Castañón MJ, Miranda-Ordieres AJ, Tuñón-Blanco P, Carriedo GA, García-Alonso FJ, Fidalgo JI (2001) Electroanalysis 13:1399–1404CrossRefGoogle Scholar
  11. 11.
    Kobayashi T, Wang HY, Fujii N (1998) Anal Chim Acta 365:81–88CrossRefGoogle Scholar
  12. 12.
    Wang HY, Kobayashi T, Fujii N (1996) Langmuir 12:4850–4856CrossRefGoogle Scholar
  13. 13.
    Wang HY, Kobayashi T, Fukaya T, Fujii N (1997) Langmuir 13:5396–5400CrossRefGoogle Scholar
  14. 14.
    Kobayashi T, Murawaki Y, Reddy PS, Abe M, Fujii N (2001) Anal Chim Acta 435:141–149CrossRefGoogle Scholar
  15. 15.
    Dickert FL, Halikias KP, Hayden O, Piv L, Sikorski R (2001) Sens Actuators B 76:295–298CrossRefGoogle Scholar
  16. 16.
    Lahav M, Kharitonov AB, Katz O, Kunitake T, Willner I (2001) Anal Chem 73:720–723CrossRefPubMedGoogle Scholar
  17. 17.
    Makote R, Collinson M (1998) Chem Mater 10:2240–2445CrossRefGoogle Scholar
  18. 18.
    Piletsky SA, Piletskaya EV, Sergeyeva TA, Panasyuk TL, El’skaya AV (1999) Sens Actuators B 60:216–220CrossRefGoogle Scholar
  19. 19.
    Dickert FL, Hayden O, Halikias KP (2001) Analyst 126:766–771CrossRefPubMedGoogle Scholar
  20. 20.
    Kriz D, Mosbach K (1995) Anal Chim Acta 300:71–75CrossRefGoogle Scholar
  21. 21.
    Kroger S, Turner APF, Mosbach K, Haupt K (1999) Anal Chem 71:3698–3702CrossRefPubMedGoogle Scholar
  22. 22.
    Kirsch N, Hart JP, Bird DJ, Luxton RW, McCalley DV (2001) Analyst 126:1936–1941CrossRefPubMedGoogle Scholar
  23. 23.
    Tan Y, Nie L, Yao S (2001) Analyst 126:664–668CrossRefPubMedGoogle Scholar
  24. 24.
    Tan Y, Zhou Z, Wang P, Nie L, Yao S (2001) Talanta 55:337–347CrossRefGoogle Scholar
  25. 25.
    Liang C, Peng H, Bao X, Nie L, Yao S (1999) Analyst 124:1781–1785CrossRefPubMedGoogle Scholar
  26. 26.
    Liang C, Peng H, Zhou A, Nie L, Yao S (2000) Anal Chim Acta 415:135–141CrossRefGoogle Scholar
  27. 27.
    Kugimiya A, Takeuchi T (1999) Electroanalysis 11:1158–1160CrossRefGoogle Scholar
  28. 28.
    Haupt K, Noworyta K, Kutner W (1999) Anal Commun 36:391–393CrossRefGoogle Scholar
  29. 29.
    Percival CJ, Stanley S, Galle M, Braithwaite A, Newton MI, McHale G, Hayes W (2001) Anal Chem 73:4225–4228CrossRefPubMedGoogle Scholar
  30. 30.
    Kriz D, Ramstrom O, Svensson S, Mosbach K (1995) Anal Chem 67:2142–2144Google Scholar
  31. 31.
    Panasyuk-Delaney T, Mirsky VM, Ulbritch M, Wolfbeis OS (2001) Anal Chim Acta 435:157–162CrossRefGoogle Scholar
  32. 32.
    Schweitz L, Spégel P, Nilsson S (2000) Analyst 125:1899–1901CrossRefPubMedGoogle Scholar
  33. 33.
    Blanco-López MC, Lobo-Castañón MJ, Miranda-Ordieres AJ, Tuñón-Blanco P (2003) Biosens Bioelectron 18:353–362CrossRefPubMedGoogle Scholar
  34. 34.
    Spivak DA, Shea KJ (2001) Anal Chim Acta 435:65–74CrossRefGoogle Scholar
  35. 35.
    Lahav M, Kharitonov AB, Katz O, Kunitake T, Willner I (2001) Anal Chem 73:720–723CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • M. C. Blanco-López
    • 1
  • S. Gutiérrez-Fernández
    • 1
  • M. J. Lobo-Castañón
    • 1
  • A. J. Miranda-Ordieres
    • 1
  • P. Tuñón-Blanco
    • 1
    Email author
  1. 1.Departamento de Química Física y Analítica, Facultad de QuímicaUniversidad de OviedoOviedoSpain

Personalised recommendations