Analytical and Bioanalytical Chemistry

, Volume 377, Issue 3, pp 528–539 | Cite as

Present and future of surface plasmon resonance biosensors

  • Jiří HomolaEmail author


Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves—surface plasmon-polaritons—to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors.


Optical sensor Biosensor Affinity biosensor Immunosensor Surface plasmon resonance 



This work was supported by the Grant Agency of the Czech Republic under contracts 102/03/0633, 303/03/0249, and 203/02/1326.


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Institute of Radio Engineering and ElectronicsAcademy of Sciences of the Czech RepublicPragueCzech Republic

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