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Analytical and Bioanalytical Chemistry

, Volume 377, Issue 2, pp 257–261 | Cite as

Voltammetric response of diclofenac-molecularly imprinted film modified carbon electrodes

  • M. Carmen Blanco-López
  • María-Jesús Lobo-Castañón
  • Arturo J. Miranda-Ordieres
  • Paulino Tuñón-BlancoEmail author
Special Issue Paper

Abstract.

A voltammetric sensor for the determination of diclofenac was developed, based on the molecular recognition of the analyte by molecularly imprinted methacrylate-ethyleneglycol dimethacrylate co-polymers. Pre-polymerisation solutions were deposited onto the surface of a glassy carbon electrode and a polymer film was obtained after spin coating control of thickness and in situ thermal polymerisation. After the template extraction from the resultant film, re-binding of diclofenac is performed from acetonitrile solutions containing the analyte. The amount of bonded diclofenac was then evaluated by differential pulse voltammetry in different electrolytes. The best results were obtained in 0.025 M citrate solution pH 6 containing 10% of acetonitrile. This medium favours the release of diclofenac from the polymer binding sites. In this way, the voltammetric transduction of the molecular recognition event is achieved. Voltammetric selectivity measurements revealed negligible interferences from diclofenac family of anti-inflammatory drugs, such as niflumic or meclofenamic acids.

Keywords

Molecularly imprinted polymers Voltammetry Diclofenac Voltammetric sensor 

Notes

Acknowledgements.

The work has been carried out under the financial support of the Spanish government (Ministerio de Ciencia y Tecnología, project BQ-2002–00261).

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • M. Carmen Blanco-López
    • 1
  • María-Jesús Lobo-Castañón
    • 1
  • Arturo J. Miranda-Ordieres
    • 1
  • Paulino Tuñón-Blanco
    • 1
    Email author
  1. 1.Departamento de Química Física y AnalíticaUniversidad de OviedoOviedoSpain

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