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Analytical and Bioanalytical Chemistry

, Volume 377, Issue 3, pp 446–468 | Cite as

Current research activity in biosensors

  • Hideaki Nakamura
  • Isao KarubeEmail author
Review

Abstract

Biosensors consist of a molecular recognition element and a transducer. Since the first biosensor was developed by Updike and Hicks [1] many biosensors and their associated techniques have been studied and developed. In this review current research activity on the fundamentals and applications of biosensors is summarized. In discussion of the former, molecular recognition elements, techniques and tools for biosensor construction, and basic biosensor devices are introduced. Coverage of the latter includes description of biosensors for environmental, food, and clinical fields. Chemical sensors developed in our laboratory for environmental monitoring are also described. This review mainly summarizes work performed by our group and by our colleagues, and refers to the main review articles summarizing each field of biosensor research in recent years.

Keywords

Biosensor Molecular recognition element Array Environmental biosensor Food biosensor Clinical biosensor 

Abbreviations

General

BMP

Bacterial magnetic particle

BOD

Biological oxygen demand

CE

Capillary electrophoresis

CL

Chemiluminescence

COD

Chemical oxygen demand

ECL

Electrochemiluminescence

FIA

Flow-injection analysis

FP

Fluorescence polarization

HMDS

Hexamethyldisiloxane

ICS

Ion-channel switch

LED

Light emitting diodes

LIF

Laser induced fluorescence

MIP

Molecularly imprinting polymers

MRE

Molecular recognition element

PCR

Polymerase chain reaction

PNA

Peptide nucleic acid

PVA-SbQ

Poly(vinyl alcohol) bearing styrylpyridinium groups

QCM

Quartz crystal microbalance

SAM

Self-assembled monolayer

SMBG

Self monitoring of blood glucose

SPR

Surface plasmon resonance

SPV

Surface photo voltage

TiO2

Titanium dioxide

dsDNA

Double-stranded DNA

ssDNA

Single-stranded DNA

μTAS

Micro-total analysis system

Enzymes

AChE

Acetylcholinesterase

ARP

Arthromyces ramosus peroxidase

GOD

Glucose oxidase

POD

Peroxidase

PQQ-GDH

Pyrrolo-quinoline quinone glucose dehydrogenase

PyrOx

Pyruvate oxidase

Microbes

1

Aeromonas sp.

2

Aeropyrum pernix

3

Alcaligenes faecalis

4

Alexandrium affine

5

Arthrobacter nicotianae

6

Arthromyces ramosus

7

Aspergillus niger

8

Candida albicans

9

Chattonella marina

10

Cypridina luciferin

11

Erwinia sp.

12

Escherichia coli

13

Flavobacterium balustinum

14

Gluconobacter oxydans

15

Heterosigma carterae

16

Klebsiella pneumoniae

17

Kluyveromyces marxianus

18

Listeria monocytogenes

19

Magnetospirillum sp.

20

Microcystis aeruginosa

21

Pseudomonas aeruginosa

22

Pseudomonas fluorescens

23

Pseudomonas putida

24

Pseudomonas stutzeri

25

Saccharomyces cerevisiae

26

Salmonella enteritidis

27

Salmonella typhimurium

28

Serratia marcescens

29

Staphylococcus aureus

30

Thiobacillus ferrooxidans

31

Tricosporon cutaneum

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.School of BionicsTokyo University of TechnologyTokyo Japan

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