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Analytical and Bioanalytical Chemistry

, Volume 376, Issue 8, pp 1192–1197 | Cite as

Analytical developments in toxicological investigation of drug-facilitated sexual assault

  • Adam Negrusz
  • R. E. Gaensslen
Review

Abstract

This paper gives a general overview of the drug-facilitated sexual assault phenomenon. Sexual assault perpetrated on both women and men, while incapacitated by so-called date-rape drugs, recently became the focus of many investigations conducted by law enforcement agencies in the US throughout the 1990s; an alarming increase in reports of this crime as well as in the number of scientific publications on drug-facilitated sexual assault has been observed. The list of drugs reportedly associated with sexual assault is long and among others includes flunitrazepam with other benzodiazepines such as diazepam, temazepam, clonazepam, oxazepam, as well as γ-hydroxybutyrate (GHB), ketamine, and scopolamine. We discuss the most recent analytical developments in the toxicological investigation of drug-facilitated rape designed to reveal drug presence and that may help successfully prosecute perpetrators.

Keywords

Drug-facilitated sexual assault "Date-rape" drugs Forensic toxicology NCI–gas chromatography–mass spectrometry 

References

  1. 1.
    ElSohly MA, Feng S, Salamone SJ, Brenneisen R (1999) J Anal Toxicol 23:486–489PubMedGoogle Scholar
  2. 2.
    ElSohly MA, Feng S, Salamone SJ, Wu R (1997) J Anal Toxicol 21:335–340PubMedGoogle Scholar
  3. 3.
    ElSohly MA, Salamone SJ (1999) J Anal Toxicol 23:141–146PubMedGoogle Scholar
  4. 4.
    Kilpatrick DG, Acierno R, Resnick HS, Saunders BE, Best CL (1997) J Consult Clin Psychol 65:834–847CrossRefPubMedGoogle Scholar
  5. 5.
    LeBeau M, Andollo W, Hearn WL, Baselt R, Cone E, Finkle B, Fraser D, Jenkins A, Mayer J, Negrusz A, Poklis A, Walls HC, Raymon L, Robertson M, Saady J (1999) J Forensic Sci 44:227–230PubMedGoogle Scholar
  6. 6.
    Rickert VI, Wiemann CM (1998) J Pediatrics Adolescent Gynecol 11:167–175Google Scholar
  7. 7.
    Rickert VI, Wiemann CM, Berenson AB (1999) Pediatrics 103:1–5PubMedGoogle Scholar
  8. 8.
    Federal Bureau of Investigation (2002) Uniform crime reports. http://www.fbi.gov/ucr/ucr.htm. Cited 18 Dec 2002Google Scholar
  9. 9.
    Rennison CM (1998) Criminal victimization. Changes 1997–98 with trends 1993–98. Bureau of Justice Statistics, National Crime Victimization Survey (1999), publication NCJ 176353Google Scholar
  10. 10.
    Mattila MAK, Larni HM (1980) Drugs 20:353–374PubMedGoogle Scholar
  11. 11.
    Ballenger J (1995) Benzodiazepines. In: Schatzberg A, Nemeroff C (eds) Textbook of psychopharmacology. The American Psychiatric Press, Washington, DCGoogle Scholar
  12. 12.
    Bogusz MJ, Maier R-D, Krüger K-D, Früchtnicht W (1998) J Chromatogr B 713:361–369CrossRefGoogle Scholar
  13. 13.
    Drummer OH, Syrjanen ML, Cordner SM (1993) Am J Forensic Med Pathol 14:238–243PubMedGoogle Scholar
  14. 14.
    Simmons MM, Cupp MJ (1998) Ann Pharmacother 32:117–119PubMedGoogle Scholar
  15. 15.
    Smith KM (1999) J Amer Pharmac Assoc 39:519–525Google Scholar
  16. 16.
    Raymon LP, Steele BW, Walls HC (1999) J Anal Toxicol 23:490–499PubMedGoogle Scholar
  17. 17.
    Calhoun SR, Wesson DR, Galloway GP, Smith DE (1996) J Psychoactive Drugs 28:183–189PubMedGoogle Scholar
  18. 18.
    Public Law (1996) 104–305Google Scholar
  19. 19.
    Couper FJ, Logan BK (2000) J Anal Toxicol 24:1–7PubMedGoogle Scholar
  20. 20.
    McCusker RR, Paget-Wilkes H, Chronister CW, Goldberger BA, ElSohly MA (1999) J Anal Toxicol 23:301–305PubMedGoogle Scholar
  21. 21.
    Dowd SM, Strong MJ, Janicak PG, Negrusz A (2002) J Forensic Sci 47:1101–1107PubMedGoogle Scholar
  22. 22.
    http://www.census.gov/prod/3/98pubs/98statab/cc98stab.htm. Cited 18 Dec 2002Google Scholar
  23. 23.
    Jenny C (1988) Amer J Deceases Children 14:770–772Google Scholar
  24. 24.
    Beck O, Lin Z, Brodin K, Borg S (1997) J Anal Toxicol 21:554–557PubMedGoogle Scholar
  25. 25.
    Salamone JS, Honasoge C, Brenner C, McNally AJ, Passarelli J, Goc-Szkutnicka K, Brenneisen R, ElSohly MA, Feng S (1997) J Anal Toxicol 21:341–345CrossRefPubMedGoogle Scholar
  26. 26.
    Negrusz A, Moore CM, Stockham TL, Poiser KR, Kern JL, Palaparthy R, Le NLT, Janicak PG, Levy NA (2000) J Forensic Sci 45:1031–1040PubMedGoogle Scholar
  27. 27.
    Cirimele V, Kintz P, Ludes B (1997) J Chromatogr B 700:119–129CrossRefGoogle Scholar
  28. 28.
    Fitzgerald RL, Rexin DA, Herold DA (1993) J Anal Toxicol 17:342–347PubMedGoogle Scholar
  29. 29.
    Song D, Zhang S, Kohlhof K (1996) J Chromatogr B 686:199–204Google Scholar
  30. 30.
    Baumgartner W, Berka C (1989) In-Service Continuing Educ 10:7–21Google Scholar
  31. 31.
    Harkey MR, Henderson GL, Zhou C (1991) J Anal Toxicol 15:260–265PubMedGoogle Scholar
  32. 32.
    Wilkins DG, Haughey HM, Krueger GG, Rollins DE (1995) J Anal Toxicol 19:492–498PubMedGoogle Scholar
  33. 33.
    Wilkins DG, Rollins DE, Seaman J, Haughey HM, Krueger GG, Foltz R (1995) J Anal Toxicol 19:269–274PubMedGoogle Scholar
  34. 34.
    Kintz P, Crimele V, Mangin P (1995) J Forensic Sci 40:607–610Google Scholar
  35. 35.
    Polettini A, Groppi A, Montagna M (1993) Forensic Sci Int 63:217–225PubMedGoogle Scholar
  36. 36.
    Cirimele V, Kintz P, Mangin P (1996) J Anal Toxicol 20:596–598PubMedGoogle Scholar
  37. 37.
    Cirimele V, Kintz P, Staub C, Mangin P (1997) Forensic Sci Int 84:189–200CrossRefPubMedGoogle Scholar
  38. 38.
    Kintz P, Cirimele V, Vaysette F, Mangin P (1996) J Chromatogr 677:241–244CrossRefGoogle Scholar
  39. 39.
    Kintz P, Tracqui A, Mangin P (1992) Int J Legal Med 105:1–4PubMedGoogle Scholar
  40. 40.
    Negrusz A, Moore C, Deitermann D, Lewis D, Kaleciak K, Kronstrand R, Feeley B, Niedbala RS (1999) J Anal Toxicol 23:429–435PubMedGoogle Scholar
  41. 41.
    Yegles M, Mersch F, Wennig R (1997) Forensic Sci Int 84:211–218CrossRefPubMedGoogle Scholar
  42. 42.
    Negrusz A, Moore CM, Kern JL, Janicak PG, Strong MJ, Levy NA (2000) J Anal Toxicol 24:614–620PubMedGoogle Scholar
  43. 43.
    Negrusz A, Moore CM, Hinkel K, Stockham TL, Verma M, Strong MJ, Janicak PG (2001) J Forensic Sci 46:1143–1151PubMedGoogle Scholar
  44. 44.
    Negrusz A, Bowen AM, Moore CM, Dowd SM, Strong MJ, Janicak PG (2002) J Anal Toxicol 26:471–478PubMedGoogle Scholar
  45. 45.
    Goddard M, Sexual assault: a hospital/community protocol for forensic and medical examination. Washington DC: US Dept of Justice, Office of Justice Programs, Office for Victims of Crime, Final Report, Grant # 85-SN-CX-0009Google Scholar
  46. 46.
    Lee HC, Gaensslen RE (1996) Sexual Assault Evidence—National Assessment and Guidebook. Washington DC: US Dept of Justice, National Institute of Justice, Draft Final Report, Grant # 92-IJ-CX-0041Google Scholar

Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Forensic Science Program, Department of Biopharmaceutical Sciences (M/C 865), College of PharmacyUniversity of Illinois at ChicagoChicagoUSA

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