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Analytical and Bioanalytical Chemistry

, Volume 373, Issue 6, pp 399–403 | Cite as

Integrated CMOS microchip system with capillary array electrophoresis

  • Joon Song
  • Tuan Vo-Dinh
Review

Abstract.

A complementary metal oxide semiconductor (CMOS)–capillary array electrophoresis (CAE) system has been used for DNA analysis. Because of its compactness and multiplex capability, the CAE-CMOS microchip is very suitable for the construction of a miniaturized high-throughput system for bioassays. Use of simultaneous laser-beam focusing on to the capillary array and a microscope objective contributed to the construction of the compact CMOS microchip–CAE system. To test the constructed system 100-base-pair (bp) DNA ladders and Hind III digest λ DNA were separated in poly(vinylpyrrolidone) (PVP) sieving matrix. The miniaturized and integrated CMOS microchip system used in this work had great potential for combination with a variety of microfabricated devices for biomedical research.

CMOS microchip Capillary array electrophoresis Miniaturization DNA separation 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Joon Song
    • 1
  • Tuan Vo-Dinh
    • 1
  1. 1.Advanced Biomedical Science and Technology Group, Life Sciences Division, Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, Tennessee 37831–6101USA

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